Lactococcus Ceduovirus Phages Isolated from Industrial Dairy Plants-from Physiological to Genomic Analyses.

Viruses
Magdalena Chmielewska-JeznachAgnieszka K Szczepankowska

Abstract

Lactococcus Ceduovirus (formerly c2virus) bacteriophages are among the three most prevalent phage types reported in dairy environments. Phages from this group conduct a strictly lytic lifestyle and cause substantial losses during milk fermentation processes, by infecting lactococcal host starter strains. Despite their deleterious activity, there are limited research data concerning Ceduovirus phages. To advance our knowledge on this specific phage group, we sequenced and performed a comparative analysis of 10 new Lactococcus lactis Ceduovirus phages isolated from distinct dairy environments. Host range studies allowed us to distinguish the differential patterns of infection of L. lactis cells for each phage, and revealed a broad host spectrum for most of them. We showed that 40% of the studied Ceduovirus phages can infect both cremoris and lactis strains. A preference to lyse strains with the C-type cell wall polysaccharide genotype was observed. Phage whole-genome sequencing revealed an average nucleotide identity above 80%, with distinct regions of divergence mapped to several locations. The comparative approach for analyzing genomic data and the phage lytic spectrum suggested that the amino acid sequence of the orf8-encoded ...Continue Reading

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Datasets Mentioned

BETA
GM17

Methods Mentioned

BETA
electron microscopy
X-ray
PCR
Illumina Sequencing

Software Mentioned

Mafft
BLAST
Newbler
ClustalOmega
fastp
RAST
Rapid Annotation Subsystem Technology ( RAST )
BLASTp
HHPRED
MPI Bioinformatics Tool Kit ( HHPRED

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