Lactoferrin--50 years on

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Jeremy H Brock

Abstract

It is now some 50 years since iron-binding lactoferrin was first isolated and purified, an event that opened the way to subsequent extensive research on lactoferrin structure and function. The initial recognition that lactoferrin closely resembled the plasma iron-transport protein transferrin meant that lactoferrin was first thought to mediate intestinal iron absorption or to act as an antimicrobial agent. It was also suggested that it could mediate the hyposideraemia of inflammation. This paper will assess to what extent early proposals have stood the test of time and also suggest possible mechanisms by which lactoferrin can mediate the large number of potential functions that have subsequently been proposed. It will also review the ability of lactoferrin to resist digestion in the gastrointestinal tract and identify areas for future research.

References

Oct 24, 1979·Biochimica Et Biophysica Acta·E H Morgan
Jul 15, 1977·Science·R R ArnoldJ R McGhee
Sep 28, 1976·Biochimica Et Biophysica Acta·J H BrockA Piñeiro
May 22, 1992·Biochimica Et Biophysica Acta·W BellamyM Tomita
Feb 1, 1991·Acta paediatrica Scandinavica·G Schulz-LellJ Schaub
Dec 1, 1987·Pediatric Research·S J Fairweather-TaitM J Minski
Oct 1, 1974·The Journal of Experimental Medicine·J L Van SnickJ F Heremans
Dec 23, 1968·Biochimica Et Biophysica Acta·J D Oram, B Reiter
Sep 1, 1969·The Journal of Experimental Medicine·P L MassonE Schonne
May 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P L Masson, J F Heremans
Mar 1, 1970·The Journal of Experimental Medicine·M BaggioliniJ F Heremans
Mar 1, 1980·The Journal of Pediatrics·G B Fransson, B Lönnerdal
Nov 1, 1995·Infection and Immunity·J M TurchanyF D Gillin
Jan 1, 1994·Pediatric Research·L DavidssonR F Hurrell
Jun 1, 1994·Infection and Immunity·B J AppelmelkJ H Nuijens
Jul 1, 1996·Experimental Parasitology·J TachezyJ Schrével
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·J QiuA G Plaut
Aug 2, 2001·The Journal of Nutrition·F J TroostR J Brummer
May 31, 2002·Nature·Pradeep K SinghMichael J Welsh
Dec 17, 2002·Molecular and Cellular Biology·Pauline P WardOrla M Conneely
Dec 18, 1960·Biochimica Et Biophysica Acta·J MONTREUILS MULLET
Jan 14, 2004·European Journal of Biochemistry·Dominique LegrandAra G Hovanessian
Jun 30, 2004·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Lucilla SegantiFabiana Superti
Jun 30, 2004·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kinya AshidaBo Lönnerdal
Sep 29, 2004·Antiviral Research·Leonie BeljaarsDirk K F Meijer
Nov 2, 2005·Cellular and Molecular Life Sciences : CMLS·P Valenti, G Antonini
Nov 2, 2005·Cellular and Molecular Life Sciences : CMLS·Y A SuzukiB Lönnerdal
Dec 13, 2005·Microbiology·Nidia León-SicairosMireya de la Garza
Feb 14, 2006·The American Journal of Clinical Nutrition·Bo Lönnerdal, Annika Bryant
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nidia León-SicairosMireya de la Garza
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Rosalba PaesanoPiera Valenti

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Citations

Jun 3, 2014·Current Tropical Medicine Reports·Christie G Turin, Theresa J Ochoa
Jul 6, 2014·Biointerphases·Futami Nagano-TakebeKazuhiko Endo
Dec 3, 2014·Biochemical and Biophysical Research Communications·Yaonan ZhangZhidao Xia
May 27, 2015·Nutrition Reviews·David R Hill, David S Newburg
May 15, 2015·The Pediatric Infectious Disease Journal·Theresa J OchoaUNKNOWN NEOLACTO Research Group
Mar 3, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·J TyrrellMáire Callaghan
Jun 25, 2013·Jornal de pediatria·Leticia Fuganti CamposMário Cícero Falcão
Jun 2, 2016·Korean Journal of Ophthalmology : KJO·Won Soo KimJae Chan Kim
May 29, 2016·The Journal of Pediatrics·Dominique Legrand
Jun 15, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natascia BruniFranco Dosio
Feb 7, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ruth Reyes-CortesNidia Leon-Sicairos
Jan 14, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xiao WangJianhua Wang
Jan 22, 2015·International Journal of Systematic and Evolutionary Microbiology·Sławomir JabłońskiMarcin Łukaszewicz
May 17, 2019·Current Protein & Peptide Science·Przemysław Gajda-MorszewskiMałgorzata Brindell
Mar 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li LiangHua-Hua Du
Sep 4, 2020·Experimental Biology and Medicine·Santosh R D'Mello, Mark C Kindy
Feb 23, 2020·Science Advances·Zhiming WangHongjin Zheng
Jun 24, 2020·Frontiers in Immunology·Douglas B KellEtheresia Pretorius
Jan 14, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Theresa J Ochoa, Stéphane V Sizonenko
Mar 17, 2017·Journal of Immunology Research·Tie-Shan TengYan-Zhang Li
Oct 27, 2018·Expert Opinion on Therapeutic Targets·Éva LeiterIstván Pócsi
Jan 11, 2019·Biochemical Society Transactions·Stephanie L Begg
Jan 1, 2013·ISRN Biochemistry·Massimo Masserini
Jul 4, 2018·Nutrients·Olaf PerdijkSylvia Brugman
Feb 25, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sheridan L HelmanDavid M Frazer
Dec 2, 2020·Animals : an Open Access Journal From MDPI·Vittorio SaettoneGiorgia Meineri
Jun 30, 2019·Current Drug Discovery Technologies·Debaprasad ParaiSamir K Mukherjee
Apr 9, 2021·Journal of Hematology & Oncology·Lingyu WeiJian Ma
May 4, 2021·International Journal of Surgical Pathology·Mingfei YanHannah Gilmore

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