Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology

Mediators of Inflammation
Jeffrey K Actor

Abstract

There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a "firebreak" to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or stop development of aggressive destructive pulmonary pathology. Lactoferrin, an iron-binding glycoprotein found in mucosal secretions and granules of neutrophils, is just such a potential adjunct therapeutic agent. The focus of this review is to explore the utility of lactoferrin to serve as a therapeutic tool to investigate "disruption" of the mycobacterial granuloma. Proposed concepts for mechanisms underlying lactoferrin efficacy to control immunopathology are supported by data generated based on in vivo models using nonpathogenic trehalose 6,6'-dimycolate (TDM, cord factor).

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Citations

Feb 7, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shen-An HwangJeffrey K Actor
Nov 23, 2017·Frontiers in Immunology·Marian L KruzelJeffrey K Actor
May 14, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Thao K T NguyenJeffrey K Actor
Mar 26, 2021·International Immunopharmacology·Michał ZimeckiMarian L Kruzel
Jun 3, 2020·Mucosal Immunology·Rustin R LovewellChristopher M Sassetti

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Methods Mentioned

BETA
glycosylation

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