Lactoferrin for the treatment of COVID-19 (Review)

Experimental and Therapeutic Medicine
Yidan WangYang Chu

Abstract

The coronavirus disease 2019 (COVID-19) outbreak was caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical outcomes of elderly individuals and those with underlying diseases affected by COVID-19 are serious, and may result in acute respiratory distress syndrome (ARDS) and even mortality. Currently, the clinical treatments for COVID-19 mostly involve symptom alleviation measures and non-specific broad spectrum antiviral drugs, as highly effective antiviral drugs and vaccines are not yet available. Lactoferrin (LF) is a safe iron-binding glycoprotein that is present in the milk of the majority of mammals and exhibits broad-spectrum antiviral activity, including against coronaviruses. In addition, LF also exhibits anti-inflammatory, anti-infective and immune-regulating properties, which are in line with the treatment requirements for SARS-CoV-2 infection. Therefore, the use of LF may be of value in the prevention and/or management of COVID-19. The aim of the present review was to summarize the previous reports on the antiviral properties of LF and compare these with the characteristics of SARS-CoV-2 infection, in order to determine whether LF could be used to assist in the preventi...Continue Reading

Associated Clinical Trials

Apr 19, 2021·Paolo Manzoni Study Group, Paolo Manzoni Study Group

Citations

Jan 28, 2021·Nutrients·Claudio SalarisIgnazio Castagliuolo
Feb 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isabella RomeoStefano Alcaro
Mar 7, 2021·Nutrients·Daniela MorniroliMaria Lorella Giannì
Mar 26, 2021·International Immunopharmacology·Michał ZimeckiMarian L Kruzel
Apr 9, 2021·Computer Methods and Programs in Biomedicine·Mohamed TalaatJinxiang Xi
Jun 3, 2021·International Journal of Environmental Research and Public Health·Flaminia BardanzelluVassilios Fanos
Jul 3, 2021·International Journal of Molecular Sciences·Valeria De PasqualeLuigi Michele Pavone
Jul 14, 2021·Ocular Immunology and Inflammation·Oksan Alpogan, Sarper Karakucuk
Oct 19, 2021·ACS Pharmacology & Translational Science·Yu PanChun Loong Ho

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