Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study

Atherosclerosis
Inga Thorsen VengenVibeke Videm

Abstract

The pathogenesis of diabetes and atherosclerosis is linked through inflammation. Neutrophils contribute to atherosclerotic plaque development, and are dysfunctional in diabetes. The aim of this study was to compare the predictive values of two neutrophil degranulation products, myeloperoxidase and lactoferrin, on long-term risk for fatal ischemic heart disease in persons with newly diagnosed diabetes and controls. Prospective population-based cohort study. In 1984-1986, a large population study, HUNT 1, was conducted in Norway. Previously unknown diabetes was diagnosed in 205 persons. A matched control group without diabetes was selected from the HUNT 1. Fatal ischemic heart disease was registered until 2004. Baseline serum was analysed for myeloperoxidase and lactoferrin. Cox regression analysis with adjustments for age, gender, hypertension, body mass index, established cardiovascular disease and total cholesterol was used to estimate hazard ratios for fatal ischemic heart disease. In the diabetes group (200 subjects), the two highest tertiles of lactoferrin predicted fatal ischemic heart disease, hazard ratio 2.54 (95% CI, 1.00-6.45) and 4.06 (1.72-9.60). Myeloperoxidase did not predict death from ischemic heart disease in s...Continue Reading

References

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Citations

Feb 1, 2013·Journal of Cardiovascular Pharmacology·Yasumasa IkedaToshiaki Tamaki
Mar 13, 2012·Human Immunology·Vibeke VidemRune Wiseth
Nov 6, 2009·Revista española de cardiología·Pablo AvanzasJuan Carlos Kaski
Mar 17, 2016·Antioxidants & Redox Signaling·Sylvain MayeurEmile Levy
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Benedicto Crespo-FacorroJesus Sainz
May 18, 2016·Journal of Diabetes Investigation·Juan HuangZhiguang Zhou
Aug 25, 2019·Nutrients·Małgorzata JamkaJarosław Walkowiak
Dec 14, 2018·Basic Research in Cardiology·Mira JungThomas Thum
Feb 23, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Youngsik SeoHeonyong Park

Related Concepts

Diabetes Mellitus, Non-Insulin-Dependent
Inflammation
Lactoferrin
Peroxidase
Neutrophil Band Cells
Incidence Studies
Cox Proportional Hazards Models
Myocardial Ischemia
Atherosclerosis
Biological Markers

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