Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery

Materials Science & Engineering. C, Materials for Biological Applications
Meng-Meng SongYu-Xian Shen

Abstract

Targeting delivery of drugs in a specific manner represents a potential powerful technology in gliomas. Herein, we prepared a multifunctional targeted delivery system based on graphene oxide (GO) that contains a molecular bio-targeting ligand and superparamagnetic iron oxide nanoparticles on the surface of GO for magnetic targeting. Superparamagnetic Fe3O4 nanoparticles was loaded on the surface of GO via chemical precipitation method to form GO@Fe3O4 nanocomposites. Lactoferrin (Lf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells and vascular endothelial cell of the blood brain barrier, was chosen as the targeted ligand to construct the targeted delivery system Lf@GO@Fe3O4 through EDC/NHS chemistry. With the confirmation of TEM, DLS and VSM, the resulting Lf@GO@Fe3O4 had a size distribution of 200-1000nm and exhibited a superparamagnetic behavior. The nano delivery system had a high loading capacity and exhibited a pH-dependent release behavior. Compared with free DOX and DOX@GO@Fe3O4, Lf@GO@Fe3O4@DOX displayed greater intracellular delivery efficiency and stronger cytotoxicity against C6 glioma cells. The results demonstrated the potential utility of Lf conjugated ...Continue Reading

Citations

Feb 24, 2018·Materials·Lazhen ShenYongsheng Qiao
Mar 3, 2018·International Journal of Environmental Research and Public Health·Gaurav SharmaU M H Aqil
Jun 15, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fernanda Rodriguez-OtorminMaría J Vicent
May 8, 2018·Journal of Drug Targeting·Lingyun YiGuangxi Zhai
Oct 24, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qing GuoShun-Qing Xu
May 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marcelo de SousaOswaldo L Alves
Sep 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Neha KarkiNanda Gopal Sahoo
Feb 29, 2020·Dose-response : a Publication of International Hormesis Society·Meng YangDongliang Shi
Dec 6, 2017·Advanced Healthcare Materials·Pavla MartinkovaMiroslav Pohanka
Nov 20, 2020·International Journal of Biological Macromolecules·Mona M Agwa, Sally Sabra
Nov 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yanli ZhangLongquan Shao
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Taicheng LuXuehua Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.