Lactoferrin receptors in gram-negative bacteria: insights into the iron acquisition process

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Andrew EkinsAnthony B Schryvers

Abstract

One component of the anti-microbial function of lactoferrin (Lf) is its ability to sequester iron from potential pathogens. To overcome this iron limitation, a number of gram-negative bacterial pathogens have developed a mechanism for acquiring iron directly from this host glycoprotein. This mechanism involves surface receptors capable of specifically binding Lf from the host, removing iron and transporting it across the outer membrane. The iron is then bound by a periplasmic iron-binding protein, FbpA, and transported into the cell via an inner membrane complex comprised of FbpB and FbpC. The receptor has been shown to consist of two proteins, LbpA and LbpB. LbpB is bilobed lipoprotein anchored to the outer membrane via fatty acyl groups attached to the N-terminal cysteine. LbpA is a homologue of siderophore receptors, which consist of an N-terminal plug and a C-terminal beta-barrel region. We propose that the receptor proteins, LbpA and LbpB, induce conformational changes in human Lf (hLf) that lower its affinity for iron that binding by FbpA can drive the transport across the outer membrane, a mechanism shared with transferrin (Tf) receptors. The interaction between the receptor proteins and Lf is quite extensive and has bee...Continue Reading

Citations

Jan 22, 2008·Journal of Bacteriology·Claire E MillerJulian M Ketley
Jun 12, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Po-Wen ChenFang-Yi Chu
Feb 18, 2010·Metallomics : Integrated Biometal Science·Claire J Parker SiburtAlvin L Crumbliss
Oct 1, 2010·Nanoscale·Paulrajpillai Lourdu XavierThalappil Pradeep
Nov 28, 2006·Microbial Pathogenesis·Roger S GeertsemaLynette B Corbeil
Dec 8, 2010·Proteomics. Clinical Applications·Henry J WindleDermot P Kelleher
Aug 31, 2010·The Biochemical Journal·Husain K KhambatiAnthony B Schryvers
Sep 22, 2011·Biochimica Et Biophysica Acta·Claire J Parker SiburtAlvin L Crumbliss
May 24, 2015·Applied and Environmental Microbiology·Xiaolan WangShengqing Yu
Nov 15, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Malcom G P Page
Jun 8, 2021·Microbiological Research·Behnoush KhasheiiAbdolmajid Mohammadzadeh
Sep 24, 2009·Chemical Reviews·Moriah Sandy, Alison Butler

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