PMID: 7033394Jan 1, 1982Paper

Lactoperoxidase-catalyzed iodination of membrane proteins in normal and neoplastic epidermal cells

The Journal of Investigative Dermatology
M M Brysk, J M Snider

Abstract

Cell surface proteins of normal human, mouse, and rat cells in primary culture, of human basal cell carcinoma, and of carcinogen-transformed cell lines were examined by lactoperoxidase-catalyzed iodination. Autoradiography was used to record the distribution of label in the polypeptide subunits separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis. There was no significant difference in the results for normal cells of human, mouse, and rat. On the other hand, carcinogen-transformed mouse cells had many more labeled polypeptide bands of widely distributed molecular weights. The iodination profiles from human basal cell carcinoma cells were much more akin to those from normal cells than to those from carcinogen-transformed cells. Treatment of iodinated cells with proteolytic enzymes visibly altered the polypeptide bands.

References

Jan 28, 1975·Biochimica Et Biophysica Acta·R L Juliano, M Behar-Bannelier
May 1, 1974·Experimental Cell Research·S H Yuspa, C C Harris
Mar 1, 1971·The Journal of Investigative Dermatology·M A Karasek, M E Charlton
Oct 1, 1970·Journal of Ultrastructure Research·I Brody
May 11, 1971·Biochemistry·D R Phillips, M Morrison
Jun 1, 1980·The British Journal of Dermatology·P R MannG M Gray
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R K BrabecI J Goldstein

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Citations

Nov 1, 1983·The British Journal of Dermatology·A L KariniemiI Virtanen
Dec 1, 1987·International Journal of Dermatology·L M DiCiccoJ N Mansbridge
Apr 1, 1984·The Journal of Investigative Dermatology·R E Gates, L E King
Sep 1, 1982·The Journal of Investigative Dermatology·M M Brysk, J M Snider

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