PMID: 3753965Jan 1, 1986Paper

Lactoquinomycin B, a novel antibiotic

The Journal of Antibiotics
T OkabeN Tanaka

Abstract

Streptomyces tanashiensis IM8442T was found to produce lactoquinomycin B, a novel antibiotic, together with lactoquinomycin A. Lactoquinomycin B was purified, and the physico-chemical and biological characteristics were studied. Lactoquinomycin B, C24H27NO9, mp 149-152 degrees C (dec), FD-MS m/z 473 (M+), is a basic substance, showing UV lambda MeOHmax (epsilon) 239 (15,100), 287 (3,450) and 369 nm (5,300), and IR nu CHCl3max 1790 (gamma-lactone), and 1700 and 1650 (quinone) cm-1. The structure of lactoquinomycin B was elucidated by 1H NMR and 13C NMR in comparison with those of lactoquinomycin A, indicating that B is a 4a,10a-epoxide derivative of A. Lactoquinomycin B displayed inhibitory activity against bacteria, particularly Gram-positive organisms, and cytotoxicity against human and murine tumor cell lines. LD50 for mice was ca. 40 mg/kg by iv route.

Citations

Sep 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tanja Thorskov BladtThomas Ostenfeld Larsen
Oct 5, 2019·Chemical Science·Yinan ZhangJon S Thorson
Feb 8, 2018·Natural Product Research·Rodney LacretFernando Reyes
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson
Sep 14, 2018·Journal of Natural Products·Yong-Jun JiangZhong-Jun Ma

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