PMID: 8959351Dec 1, 1996Paper

Lactose handling by women with lactose malabsorption is improved during pregnancy

Clinical and Investigative Medicine. Médecine Clinique Et Experimentale
A SzilagyiE Seidman

Abstract

To evaluate lactose handling among women in late pregnancy and post partum to determine whether lactose handling is altered in pregnancy. Prospective study of lactose intolerance among pregnant women with and without lactose malabsorption. Gastroenterology service of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal. Thirty-three pregnant women, of whom 18 had lactose malabsorption, 12 did not and 3 were excluded. Lactose breath hydrogen (BH2) concentration after ingestion of lactose or lactulose; comparison before and after delivery of area under the curve (AUC) for lactose, oral-cecal transit time (OCTT) for lactulose, lactose-BH2-derived transit time and estimated dietary lactose consumption. After weaning (at a median time of 9 months after delivery), 28 of the women returned for follow-up. Of the 12 who could absorb lactose before delivery, 4 could no longer absorb lactose. Of the other 16 women, lactose intolerance worsened in 12, remained the same in 2 and improved in 2. The AUC was greater (p < 0.005), the maximal BH2 concentration was higher (p = 0.004) and the number of women whose BH2 concentration peaked was fewer (p < 0.025) post partum than before delivery. The women's symptoms during and after lactose B...Continue Reading

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