Lactose malabsorption and intolerance: a review

Food & Function
Santiago Ugidos-RodríguezMaría Cortes Sánchez-Mata

Abstract

Food lactose and lactose intolerance are today hot topics in the field of food and nutrition. About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-d-galactosidase found in the apical surface of the intestinal microvilli. This may be due to the loss of intestinal lactase in adulthood, a condition transmitted by an autosomal recessive gene, which differs in humans according to race. According to the cultural-historical hypothesis, the mutation that allows the metabolization of lactose appeared about 10 000 years ago in the inhabitants of Northern Europe where mammalian milk continued in the diet after weaning, and lactase-persistent populations were genetically selected in some areas. Many intolerant individuals can tolerate low levels of lactose in their daily diet. Probiotics have also been proposed as an alternative that could avoid some symptoms of lactose intolerance. Many products are marketed nowadays as alternatives to dairy products for lactose-intolerant individuals. However, the rules for low-lactose foods are currently not harmonised in the European Union. As scientific knowledge on lactose intolerance has notably adv...Continue Reading

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Citations

May 11, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Andrea StrazzulliMarco Moracci
Jul 10, 2020·Critical Reviews in Food Science and Nutrition·Wolfgang J Schnedl, Dietmar Enko
Feb 13, 2020·Current Pharmaceutical Design·Rafael Guille SeoaneDamián Cordoba-Diaz
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May 22, 2019·Clinical Case Reports·Sigrid von ManitiusAna Paula Simões-Wüst
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Mar 18, 2021·Food & Function·Lorenzo NissenAndrea Gianotti
Dec 29, 2020·Journal of Neurogastroenterology and Motility·Michel BouchouchaRobert Benamouzig
Apr 9, 2021·Journal of the American College of Nutrition·Gunjan Kumari KatochPrasad Rasane
Apr 23, 2021·Nutrition Research·Roberto CatanzaroFrancesco Marotta
Jun 3, 2021·Journal of Fungi·Stefano VarrellaCinzia Corinaldesi
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Apr 6, 2020·Food Research International·Aline R A SilvaBernardo D Ribeiro
Nov 3, 2020·Journal of Clinical Gastroenterology·Ana D Cano-ContrerasNuria Perez Lopez

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Methods Mentioned

BETA
biopsy
biopsies
PCR

Software Mentioned

LacTEST

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