Lactulose versus polyethylene glycol for disimpaction therapy in constipated children, a randomized controlled study

Sudanese Journal of Paediatrics
Mohammad Salem ShatnawiManar Mohammad Alzu'bi

Abstract

Faecal disimpaction is very important for successful management of the constipation in children. Lactulose is cheap and widely available medicine compared to other polyethylene glycol (PEG) preparations. From our experience, lactulose is effective and safe medicine for both disimpaction and maintenance therapy in constipated children. The purpose of the present study was to evaluate the safety and efficacy of lactulose in faecal impaction management in children with constipation. We conducted a prospective controlled trial in children with functional constipation, who presented with faecal impaction to Queen Rania Hospital for Children from April 15, 2018 until October 15, 2018. Two randomised matched groups; group A included 33 constipated children treated for disimpaction with higher dose lactulose (10 g/15 ml) 4-6 ml/kg/day (max. 120 ml/day) and group B included 32 children treated for disimpaction with macrogol (PEG 4000) 1-1.5 g/kg (max. 30 g/day). Both groups received treatment until resolution or up to 6 days. Patients were followed over 1 week and success of disimpaction was observed. Moreover, any adverse events were recorded. All the patients in both groups achieved successful disimpaction by seventh day of the therap...Continue Reading

References

Sep 10, 2002·The Journal of Pediatrics·Nader N YoussefCarlo Di Lorenzo
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Sep 7, 2006·Journal of Pediatric Gastroenterology and Nutrition·UNKNOWN Constipation Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
Oct 13, 2006·The American Journal of Gastroenterology·Maartje M van den BergC Di Lorenzo
Jun 19, 2008·Current Medical Research and Opinion·Julian F GuestMarianne T Helter
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Dec 19, 2013·Journal of Pediatric Gastroenterology and Nutrition·M M TabbersM A Benninga
Aug 12, 2015·Paediatric Drugs·Ilan J N KoppenMerit M Tabbers
Aug 7, 2019·Sudanese Journal of Paediatrics·Mohammad Salem ShatnawiManar Mohammad Alzu'bi

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Aug 7, 2019·Sudanese Journal of Paediatrics·Mohammad Salem ShatnawiManar Mohammad Alzu'bi

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