Lafutidine changes levels of somatostatin, calcitonin gene-related peptide, and secretin in human plasma

Biological & Pharmaceutical Bulletin
Hiroki ItohMasaharu Takeyama

Abstract

We examined the effects of the histamine H2-receptor antagonist, lafutidine, on the levels of gastrointestinal peptides (somatostatin, calcitonin gene-related peptide (CGRP), gastrin, secretin, and motilin) in plasma from healthy subjects. After a single oral administration of lafutidine (10 mg), the plasma lafutidine level (186 +/- 13.4ng/ml) was highest in the 60-min sample after administration and then the plasma level fell. Lafutidine caused significant increase in plasma somatostatin levels at 20 to 120 min and in CGRP levels at 40 to 120 min, compared with a placebo group. The physiological release of plasma secretin was reduced by administration of lafutidine, but the medicine did not alter the level of gastrin or motilin. These results suggest that the pharmacological effects of lafutidine on regulation of gastrointestinal functions closely relate to changes of somatostatin-, CGRP- and secretin-immunoreactive substance levels in human plasma.

References

Nov 1, 1978·The American Journal of Digestive Diseases·W Y CheyH H Tai
Sep 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·S J KonturekA V Schally
Jan 1, 1978·Scandinavian Journal of Gastroenterology·C JohanssonR Luft
Sep 1, 1978·The American Journal of Physiology·P ThorA V Schally
Aug 1, 1992·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·M SeikiE Tagashira
Feb 1, 1990·Chemical & Pharmaceutical Bulletin·M TakeyamaH Yajima
Mar 14, 1989·European Journal of Pharmacology·S Katsoulis, J M Conlon
Jan 1, 1989·The American Journal of Physiology·P BauerfeindA L Blum
Jan 1, 1985·Gastroenterology·J W HollinsheadJ H Walsh
Mar 1, 1985·Regulatory Peptides·P M BellK G Alberti
Apr 21, 1972·Nature·J W BlackE M Parsons
Sep 1, 1980·The American Journal of Physiology·P PoitrasJ H Walsh
Aug 1, 1982·The American Journal of Physiology·A SealJ Walsh
Nov 1, 1982·British Journal of Pharmacology·G Bertaccini, C Scarpignato
Feb 1, 1983·Regulatory Peptides·T L PeetersG R Vantrappen
Sep 1, 1983·Canadian Journal of Physiology and Pharmacology·J E FoxS Chiu
Jun 1, 1995·Japanese Journal of Pharmacology·S OnoderaH Ohnishi
Mar 1, 1994·Biological & Pharmaceutical Bulletin·M TakeyamaK Mori
Apr 28, 1993·European Journal of Pharmacology·M ShibataH Ohnishi
Dec 1, 1993·Chemical & Pharmaceutical Bulletin·M TakeyamaK Mori
Feb 15, 1996·European Journal of Pharmacology·T IchikawaK Hotta
Nov 14, 1997·Journal of Gastroenterology·M MatsunoY Arakawa

❮ Previous
Next ❯

Citations

Oct 7, 2004·Biological & Pharmaceutical Bulletin·Fumihiko KatagiriMasaharu Takeyama
Apr 17, 2004·Journal of Gastroenterology and Hepatology·Yoshihisa NozawaMamoru Kiniwa
Feb 27, 2003·Journal of Gastroenterology and Hepatology·Hiroshi Kaneko
May 18, 2011·World Journal of Gastrointestinal Pharmacology and Therapeutics·Bhupesh Dewan, Raghuram Chimata
Nov 26, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Young CheungUNKNOWN Korean Association of Gastroenterology
May 16, 2006·Digestive Diseases·Carmelo ScarpignatoFrancesco Di Mario
Jun 2, 2021·European Journal of Clinical Pharmacology·Takahiro SuzukiTakahisa Furuta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.