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Lagging-strand replication shapes the mutational landscape of the genome

Nature

Feb 26, 2015

Martin A M ReijnsMartin Ian Taylor

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Abstract

The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleo...read more

Mentioned in this Paper

Landscapes
probe gene fragment
Chemical Substitution
Chromatin
Mutagenesis Process
Mutation Abnormality
Genome
Cell Division
Genetic Hotspot
Site
72
7
379
1
Paper Details
References
  • References58
  • Citations46
12345

Lagging-strand replication shapes the mutational landscape of the genome

Nature

Feb 26, 2015

Martin A M ReijnsMartin Ian Taylor

PMID: 25624100

DOI: 10.1038/nature14183

Abstract

The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleo...read more

Mentioned in this Paper

Landscapes
probe gene fragment
Chemical Substitution
Chromatin
Mutagenesis Process
72
7
379
1
Paper Details
References
  • References58
  • Citations46
12345

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