Lambda-carrageenan: a novel chiral selector for capillary electrophoresis

Chirality
G M Beck, S H Neau

Abstract

Lambda-carrageenan, a linear high molecular weight sulfated polysaccharide, has been employed as a chiral selector in capillary electrophoresis for the separation of enantiomers of weakly basic pharmaceutical compounds. The racemic compounds that were enantioresolved included propranolol, pindolol, tryptophanol, laudanosine and laudanosoline. In addition, the diastereomeric pair of cinchonine and cinchonidine were also resolved. Method conditions such as buffer pH, electrolyte concentration, column temperature, and chiral selector concentration were found to be important for improvement of enantioselectivity.

References

Sep 11, 1992·Journal of Chromatography·A D'Hulst, N Verbeke
Mar 20, 1991·Carbohydrate Research·T T Stevenson, R H Furneaux
Oct 1, 1994·Analytical Chemistry·A M Stalcup, N M Agyei

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Citations

Jun 22, 1999·Biomedical Chromatography : BMC·J Bojarski, H Y Aboul-Enein
Dec 31, 1998·Electrophoresis·K Verleysen, P Sandra
Feb 17, 1998·Journal of Chromatography. a·H Nishi
Jan 5, 2002·Journal of Pharmaceutical and Biomedical Analysis·Hiroyuki Nishi, Yukari Kuwahara
Feb 17, 1998·Journal of Chromatography. a·D K LloydE De Lorenzi

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