PMID: 6402758Feb 25, 1983Paper

Lambda Ig constant region genes are translocated to chromosome 8 in Burkitt's lymphoma with t(8;22)

Nucleic Acids Research
A de la ChapelleJ C Kaplan

Abstract

By in situ hybridization of normal human chromosomes with a cloned genomic probe specific for the constant region of the lambda immunoglobulin genes, band 22q11 was preferentially labelled. In two cell lines with t(8;22) derived from Burkitt's lymphoma a strong signal was noted on the 8q+ chromosome derivative, indicating that the constant region of the lambda Ig gene cluster was translocated from chromosome 22 to chromosome 8. In addition, the signal observed on the 22q- derivative chromosome was stronger than the background in one of the two cell lines tested, but not in the other. The implications are that the break point in chromosome 22 in some cases lies within the Ig gene itself or between clusters of such genes, and that different cases have different break points.

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Citations

Jan 1, 1984·European Journal of Pediatrics·C R Bartram
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Apr 1, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J van Dongen, I L Wolvers-Tettero
Oct 12, 1995·Journal of Immunological Methods·K YoshinariY Yamaguchi
Oct 1, 1984·Cancer Genetics and Cytogenetics·S KnuutilaE von Willebrand
Jan 15, 1985·Cancer Genetics and Cytogenetics·E Pimentel
Mar 15, 1986·Cancer Genetics and Cytogenetics·A A SandbergF Hecht
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C M CroceP C Nowell
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W DunnickC Dery
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C C MortonJ L Strominger
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P DariavachM P Lefranc
Feb 1, 1987·Journal of Medical Genetics·J C KaplanM F Szajnert
Jan 1, 1984·Journal of Cellular Physiology. Supplement·N C CacciaG Klein
Aug 25, 2010·Advances in Anatomic Pathology·Michele Roullet, Adam Bagg
Jan 1, 1984·Journal of Cellular Physiology. Supplement·K F MitchellP Leder
Apr 25, 1997·Journal of Molecular Biology·O IgnatovichG Winter

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