Lambda-light-chain-mediated anti-GBM disease

Nephron
J SavigeP Kincaid-Smith

Abstract

A 77-year-old man presented with macroscopic haematuria and oligo-anuric renal failure. A renal biopsy showed moderate linear glomerular basement membrane (GBM) staining with lambda light chains alone, but both circulating IgG and lambda light chain activity were present. There was no evidence of a serum or urinary paraprotein and a bone marrow biopsy was normal. Serum lambda light chains did not bind to renal GBM when examined by indirect immunofluorescence. This case suggests that light chains are capable of binding directly to epitopes in the GBM and may initiate injury although by a different mechanism from the IgG anti-GBM molecule.

Citations

Mar 30, 2012·International Urology and Nephrology·Yao-Ko Wen, Kai-I Wen
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luis CarrerasMarta Carrera
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrea J ShaerSally E Self
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F C FervenzaT R Schwab
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M Lee, E A Marks

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