PMID: 11913581Mar 27, 2002Paper

Lambert-Eaton myasthenic syndrome in children

Journal of Child Neurology
Chang-Yong TsaoJohn T Kissel

Abstract

Lambert-Eaton myasthenic syndrome is a presynaptic disorder of neuromuscular transmission. It is characterized by muscle weakness, hyporeflexia, and autonomic dysfunction. It is most often associated with small cell carcinomas of the lung. Rare cases have been reported in children. We recently encountered two children with Lambert-Eaton myasthenic syndrome associated with antibodies to P/Q-type calcium channel but without evidence of neoplasms. Both patients showed prolonged and significant improvement following cyclosporin treatment. The diagnosis of Lambert-Eaton myasthenic syndrome should be considered in children with progressive weakness and a negative work-up for the usual causes. High-frequency repetitive nerve stimulation and P/Q-type calcium-channel antibodies may confirm the diagnosis.

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Citations

Sep 14, 2011·Current Treatment Options in Neurology·Hugh J McMillanPeter B Kang
Aug 26, 2014·Seminars in Pediatric Neurology·Sonika AgarwalSuzanne L Woodbury
Jul 1, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·A Kostera-PruszczykA Kamińska
Apr 23, 2003·American Journal of Medical Genetics. Part a·William H HoffmanRoger A Vega
Jun 24, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E BosdureB Chabrol
Jan 28, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sabine VerbeekHelene Verhelst
Oct 12, 2013·Journal of Child Neurology·S PortaroC Rodolico

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