LAMC1 mRNA promotes malignancy of hepatocellular carcinoma cells by competing for MicroRNA-124 binding with CD151

IUBMB Life
Zhan-Po YangTao Liu

Abstract

Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated region (3'UTR) and suppresses migration and invasion of HCC cells through regulating LAMC1. The wild type LAMC1 miRNA response elements (MREs) facilitate expression of CD151, and this regulation is miR-124 dependent. In clinical hepatic tissues, LAMC1 and CD151 mRNAs exhibit positive correlation. Importantly, LAMC1 MREs promote HCC malignancy by absorbing miR-124 and by assisting CD151 expression. We conclude that LAMC1 mRNA acts as a trans regulator to stimulate CD151 expression by competing for miR-124 binding in HCC cells. © 2017 IUBMB Life, 69(8):595-605, 2017.

References

Mar 17, 2004·PLoS Biology·György HutvágnerPhillip D Zamore
Nov 30, 2005·Nucleic Acids Research·Caifu ChenKarl J Guegler
Jul 17, 2007·Cell·Stefan Ludwig AmeresRenée Schroeder
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chiara Braconi, Tushar Patel
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Feb 3, 2009·Nature Structural & Molecular Biology·Shuo GuMark A Kay
Feb 24, 2010·Current Opinion in Genetics & Development·Steven L PonicsanJames A Goodrich
Mar 23, 2011·Nature Genetics·Susanna ObadSakari Kauppinen
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Nov 16, 2011·Seminars in Oncology·Chiara BraconiTushar Patel
Feb 22, 2012·Nucleic Acids Research·Anthony Bugaut, Shankar Balasubramanian
May 1, 2012·Cell·Margaret S Ebert, Phillip A Sharp
May 15, 2012·Molecular Oncology·Claudia PiovanCarlo M Croce
Aug 10, 2012·Current Cancer Drug Targets·Chiara Braconi, Tushar Patel
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Oct 12, 2012·Bioinformation·Aaron L Sarver, Subbaya Subramanian
Dec 1, 2012·Briefings in Functional Genomics·Emilia Szostak, Fátima Gebauer
Dec 20, 2012·RNA·Rasmus O BakJacob Giehm Mikkelsen
Dec 25, 2012·Cell Adhesion & Migration·Monique Aumailley
Jan 15, 2013·Current Opinion in Genetics & Development·Jie JiaPaul L Fox
Mar 12, 2013·Biophysical Journal·Matteo FigliuzziAndrea De Martino
Mar 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ugo AlaPier Paolo Pandolfi
Aug 7, 2013·Molecular and Cellular Biology·Alexander de GiorgioLeandro Castellano
Sep 28, 2013·Cancer Discovery·Florian A Karreth, Pier Paolo Pandolfi
Jan 1, 2014·Cancer Letters·Jin Ding, Hongyang Wang
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
Feb 14, 2014·Frontiers in Genetics·Reena V Kartha, Subbaya Subramanian
Mar 29, 2014·TheScientificWorldJournal·Rituparno SenJayprokas Chakrabarti
Sep 28, 2014·Best Practice & Research. Clinical Gastroenterology·Cristina BosettiCarlo La Vecchia
Apr 19, 2015·Journal of Hematology & Oncology·Avencia Sanchez-Mejias, Yvonne Tay
Jul 2, 2015·Frontiers in Medicine·Michele Ghidini, Chiara Braconi
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel
Sep 8, 2015·Gynecologic Oncology·Hiroyasu KashimaIe-Ming Shih
Oct 28, 2016·Journal of Hepatocellular Carcinoma·Julius BaloghHoward P Monsour

❮ Previous
Next ❯

Citations

Aug 8, 2019·Cancer Medicine·Xinqi JiaShan Yu
Apr 16, 2020·Frontiers in Bioengineering and Biotechnology·Zi-Mei ZhangHao Lin
Aug 28, 2020·Biomarkers in Medicine·Ana E Zacapala-GómezBerenice Illades-Aguiar
Mar 31, 2021·Breast Cancer Research and Treatment·You-Quan WangWen-Ting Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.