Lamellar keratoplasty treatment of fungal corneal ulcers with acellular porcine corneal stroma

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M-C ZhangH-T Xie

Abstract

The fundamental problem of corneal transplantation is a severe shortage of donor tissues worldwide, resulting in approximately 1.5 million new cases of blindness annually. To explore an alternative to donor corneas, we conducted a clinical study in which implanted acellular porcine corneal stromas (APCSs) replaced the pathologic anterior corneas in 47 patients who had experienced fungal corneal infections. Subsequently, we demonstrated the safety and efficacy of APCSs in human keratoplasty for a minimum follow-up period of 6 months, during which time no recurrence of infection was observed. All corneal ulcers healed with the return of neovascularization. In addition, our results indicated that epithelialization occurred in all APCS grafts except four grafts; for these four, the grafts dissolved to varying degrees. Furthermore, most porcine grafts (n = 41) gradually became transparent without rejection, and an improvement of more than two lines in best corrected visual acuity (BCVA) was achieved in 34 eyes (∼72%). Finally, no patients showed any severe adverse reaction or any significant change in postoperative systemic safety indicators. Thus, we concluded that APCS grafts are safe and efficacious during lamellar keratoplasty i...Continue Reading

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Citations

Nov 10, 2015·Expert Review of Clinical Immunology·David Kc Cooper, Rita Bottino
Jan 28, 2016·Xenotransplantation·David K C CooperRita Bottino
Sep 15, 2015·The Journal of Pathology·David K C CooperDavid Ayares
Aug 2, 2015·International Journal of Surgery·Mee Kum Kim, Hidetaka Hara
Jul 9, 2016·Xenotransplantation·Richard Mathieu
Mar 25, 2016·World Journal of Transplantation·Tian YuLucia Kuffová
Nov 13, 2015·Nature·Sara Reardon
May 31, 2019·Journal of Tissue Engineering and Regenerative Medicine·Christine MölzerLucia Kuffová
Jul 23, 2019·Journal of Biomedical Materials Research. Part a·Jing LiuZuguo Liu
Oct 9, 2019·Journal of Biomaterials Applications·Tengfei PanShuting Qi
Jul 25, 2017·Transplantation·David K C CooperDavid H Sachs
Apr 23, 2019·Journal of Biomaterials Applications·Tengfei PanShuting Qi
Oct 19, 2019·Scientific Reports·Julia Fernández-Pérez, Mark Ahearne
Jan 28, 2020·Xenotransplantation·Adwin ThomasChristopher Burlak
Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao TaoDong-An Wang
Jan 4, 2020·Journal of Biomaterials Applications·Qian WangKunpeng Pang
Oct 30, 2019·Xenotransplantation·Abdulkadir IsidanBurcin Ekser
Jul 12, 2020·Journal of Tissue Engineering and Regenerative Medicine·Sonja MertschStefan Schrader
Feb 11, 2020·Frontiers in Immunology·Tianyu LuChuan Qin
May 6, 2020·Tissue Engineering. Part a·Julia Fernández-PérezMark Ahearne
Aug 7, 2020·Progress in Retinal and Eye Research·Chang Ho YoonMee Kum Kim
Apr 16, 2021·Bio-protocol·Julia Fernández-PérezMark Ahearne
Aug 20, 2020·Computer Methods and Programs in Biomedicine·Junjun PanHong Qin

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