Lamellipodia in invasion

Seminars in Cancer Biology
J S CondeelisJ E Segall

Abstract

In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution of the EGF receptor is uniform but internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; and (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.

References

Jul 21, 1995·The Journal of Biological Chemistry·B J AgnewJ R Bamburg
Feb 9, 1996·Cell·D A Lauffenburger, A F Horwitz
Feb 1, 1996·Current Opinion in Cell Biology·S H Zigmond
Jan 1, 1997·Advances in Second Messenger and Phosphoprotein Research·J L MilneP N Devreotes
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D MullinsT D Pollard
Nov 21, 1998·Cell Adhesion and Communication·G E JonesA J Ridley
Dec 19, 1998·Microscopy Research and Technique·M BaillyJ E Segall
Mar 24, 1999·The Journal of Cell Biology·C D Nobes, A Hall
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·L M MacheskyT D Pollard
Apr 10, 1999·Molecular Biology of the Cell·G ServantH R Bourne
Nov 13, 1999·Nature Cell Biology·B VanhaesebroeckA J Ridley
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·M YangR M Hoffman
Apr 1, 2000·Cell Motility and the Cytoskeleton·I IchetovkinJ S Condeelis
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J S CondeelisJ E Segall
Sep 20, 2000·The Journal of Cell Biology·R RohatgiM W Kirschner
Nov 10, 2000·Molecular Biology of the Cell·M BaillyJ E Segall

❮ Previous
Next ❯

Citations

Jul 14, 2012·Histochemistry and Cell Biology·Agnieszka Popow-WoźniakDorota Nowak
Mar 27, 2009·Breast Cancer Research and Treatment·Elena A Ostrakhovitch, Shawn S C Li
Jan 6, 2006·Molecular Biology of the Cell·Michael Rosenberg, Shoshana Ravid
Mar 29, 2012·Journal of Micro/nanolithography, MEMS, and MOEMS : JM3·Waseem Khan RajaJames Castracane
Jan 30, 2010·The Journal of Pharmacology and Experimental Therapeutics·Joseph K KiruiYaping Tu
Feb 6, 2004·Science's STKE : Signal Transduction Knowledge Environment·Stephan J Kempiak, Jeffrey E Segall
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·Delisha A StewartRobert A Sikes
Nov 11, 2005·Breast Cancer Research : BCR·Paige J BaugherSurangani F Dharmawardhane
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chris JanetopoulosPablo A Iglesias
Sep 4, 2003·The Journal of Cell Biology·Stephan J KempiakJeffrey E Segall
Jan 3, 2012·Current Opinion in Cell Biology·Jose Javier Bravo-CorderoJohn Condeelis
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Nicolas G AziosSurangani F Dharmawardhane
Apr 2, 2005·Neoplasia : an International Journal for Oncology Research·Nicolas G Azios, Suranganie F Dharmawardhane
Mar 5, 2008·Experimental Cell Research·Mirvat El-SibaiJonathan M Backer
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Wei YueLing Ping Zhu
Jul 8, 2009·International Journal of Cancer. Journal International Du Cancer·Sirpa SaloKarl Tryggvason
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer
Jun 17, 2008·Biotechnology and Bioengineering·Bobak MosadeghNoo Li Jeon
Mar 8, 2011·The EMBO Journal·Akihiro NaritaYuichiro Maéda
Feb 13, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kinga Ujfalusi-PozsonyiMiklós Nyitrai
Mar 11, 2010·Advanced Materials·Peter DomachukDavid L Kaplan
Sep 24, 2004·Experimental Cell Research·Shur-Jen WangNoo Li Jeon
Dec 15, 2004·Journal of Pharmacological and Toxicological Methods·K H S ArunP Ramarao
Sep 27, 2005·Experimental Cell Research·Sara E HeteyChristopher E Turner
Aug 2, 2005·Seminars in Cancer Biology·Burkhard BrandtThomas Dittmar
Aug 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ali Mohammad AlizadehSadaf Farsinejad
Sep 18, 2012·Current Opinion in Cell Biology·Richard L Klemke
May 15, 2013·Cellular Signalling·Samer Hanna, Mirvat El-Sibai
Nov 1, 2002·Developmental Cell·Miho IijimaPeter Devreotes
Jul 11, 2003·Developmental Cell·David R Sherwood, Paul W Sternberg
Jul 13, 2004·Biochimica Et Biophysica Acta·Michele A WozniakPatricia J Keely
Jul 28, 2009·Biochimica Et Biophysica Acta·F Bartolini, G G Gundersen
Feb 4, 2010·Physical Chemistry Chemical Physics : PCCP·Yiying HongAyusman Sen
Jul 8, 2016·SpringerPlus·P M Tchepmo Djomegni

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.