May 20, 2017

Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression

Cell
Bas van Steensel, Andrew S Belmont

Abstract

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.

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Mentioned in this Paper

Lamins
Nuclear Lamina
Blade - plant part
Cell Nucleus
Subintima
Heterochromatin
Chromosomes
Anatomical Compartments
Chromatin Location
Heterochromatin-specific nonhistone chromosomal protein HP-1

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