Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression

Cell
Bas van Steensel, Andrew S Belmont

Abstract

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.

Citations

Mar 30, 2018·Chromosoma·Anna Fortuny, Sophie E Polo
Apr 9, 2018·Biochemistry. Biokhimii︠a︡·T CremerC Cremer
Dec 16, 2017·Bioinformatics·Xiaobin Zheng, Yixian Zheng
Aug 12, 2018·Journal of Cell Science·So MaezawaSatoshi H Namekawa
Aug 10, 2018·Molecular Biology of the Cell·Shujun CaiLu Gan
Nov 20, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jyoti P ChaudhuriJoachim U Walther
Oct 26, 2018·Nature Reviews. Genetics·Abigail BuchwalterMartin W Hetzer
Oct 28, 2017·Nucleus·Anders S HansenRobert Tjian
Oct 4, 2018·Clinical Genetics·Rosettia Ho, Robert A Hegele
Jan 19, 2019·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Joanna StacheckaIzabela Szczerbal
Dec 27, 2018·Molecular Biology of the Cell·Lysie ChampionUlrike Kutay
Jan 22, 2019·Genes, Chromosomes & Cancer·Andrew J FritzRonald Berezney
Mar 20, 2019·Nature Reviews. Molecular Cell Biology·Bas van Steensel, Eileen E M Furlong
Mar 15, 2019·Nucleus·Ariadna Picart-PicoloFrédéric Pontvianne
Mar 25, 2019·Biology of the Cell·Adel Al JordAlice Meunier
Mar 6, 2019·Annual Review of Biophysics·Jyotsana J ParmarChristophe Zimmer
Jun 11, 2019·PLoS Computational Biology·Yifeng Qi, Bin Zhang
Jun 22, 2019·Nucleic Acids Research·Berta N VazquezLourdes Serrano
Jun 9, 2019·Genome Research·Lisa Barros de Andrade E SousaAnnalisa Marsico
Jun 5, 2019·Nature Reviews. Genetics·Xiao Li, Xiang-Dong Fu
Jul 4, 2019·Cells·Raquel Romero-BuenoAgnieszka Dobrzynska
Aug 11, 2019·Experimental Biology and Medicine·Matthew A CaporizzoBenjamin L Prosser
Aug 14, 2019·Nucleus·Oleg DemidovAlexei Arnaoutov
Aug 21, 2019·The Journal of Cell Biology·Chiara Mozzetta, Francesco Saverio Tedesco
Jun 5, 2019·Nutrients·Agnieszka Gadecka, Anna Bielak-Zmijewska
Oct 3, 2019·Nature Cell Biology·Adam KaroutasAsifa Akhtar
Sep 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·S S AshwinMasaki Sasai
Nov 5, 2019·PloS One·Eralda SalatajCharalampos G Spilianakis
Feb 15, 2019·Nature Reviews. Genetics·Jerry W Shay, Woodring E Wright
Oct 12, 2019·Scientific Reports·Kamel JabbariThomas Wiehe
Nov 17, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hiroaki OhishiHiroyuki Sasaki
Jan 24, 2020·ESC Heart Failure·Takatomo WatanabeGenzou Takemura
Feb 11, 2020·PLoS Computational Biology·Xiangying SunXinan H Yang
Feb 13, 2020·Briefings in Functional Genomics·Antoine CanatPierre Therizols

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