Lamina Associated Polypeptide 1 (LAP1) Interactome and Its Functional Features

Membranes
Joana B SerranoSandra Rebelo

Abstract

Lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. To date, LAP1's precise function has not been fully elucidated but analysis of its interacting proteins will permit unraveling putative associations to specific cellular pathways and cellular processes. By assessing public databases it was possible to identify the LAP1 interactome, and this was curated. In total, 41 interactions were identified. Several functionally relevant proteins, such as TRF2, TERF2IP, RIF1, ATM, MAD2L1 and MAD2L1BP were identified and these support the putative functions proposed for LAP1. Furthermore, by making use of the Ingenuity Pathways Analysis tool and submitting the LAP1 interactors, the top two canonical pathways were "Telomerase signalling" and "Telomere Extension by Telomerase" and the top functions "Cell Morphology", "Cellular Assembly and Organization" and "DNA Replication, Recombination, and Repair". Once again, putative LAP1 functions are reinforced but novel functions are emerging.

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Citations

Sep 8, 2016·Frontiers in Genetics·Jérôme D Robin, Frédérique Magdinier
Apr 16, 2020·Aging Cell·Filipa MartinsSandra Rebelo
Jul 12, 2019·Frontiers in Cell and Developmental Biology·Navjot Kaur GillAmy C Rowat
Oct 21, 2020·Biology·Cecilia ÖstlundJi-Yeon Shin

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Methods Mentioned

BETA
exome sequencing
nuclear translocation
protein folding

Software Mentioned

Panther
Excel
IPA
Cytopscape
APID
GO
Ingenuity Pathway Analysis ( IPA
Search GO data
mentha
Ingenuity Pathway Analysis

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