Lamina-specific connectivity in the brain: regulation by N-cadherin, neurotrophins, and glycoconjugates

Science
A Inoue, J R Sanes

Abstract

In the vertebrate brain, neurons grouped in parallel laminae receive distinct sets of synaptic inputs. In the avian optic tectum, arbors and synapses of most retinal axons are confined to 3 of 15 laminae. The adhesion molecule N-cadherin and cell surface glycoconjugates recognized by a plant lectin are selectively associated with these "retinorecipient" laminae. The lectin and a monoclonal antibody to N-cadherin perturbed laminar selectivity in distinct fashions. In contrast, neurotrophins increased the complexity of retinal arbors without affecting their laminar distribution. Thus, cell surface molecules and soluble trophic factors may collaborate to shape lamina-specific arbors in the brain, with the former predominantly affecting their position and the latter their size.

References

Jan 1, 1992·Annual Review of Neuroscience·L C Katz, E M Callaway
Apr 1, 1990·The Journal of Cell Biology·J L Bixby, R Zhang
Jul 7, 1988·Nature·M MatsunagaM Takeichi
Oct 27, 1995·Science·H Thoenen
Aug 1, 1993·Trends in Neurosciences·J BolzN Novak
Mar 1, 1995·Journal of Neurobiology·M Frotscher, B Heimrich
Mar 18, 1994·Brain Research. Developmental Brain Research·M IchikawaP P Graziadei
Apr 1, 1994·Neuron·S Cohen-Cory, S E Fraser
Feb 1, 1994·Current Opinion in Neurobiology·P Doherty, F S Walsh
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C J Shatz
Oct 1, 1995·Current Opinion in Cell Biology·M Takeichi
Feb 1, 1996·Current Opinion in Neurobiology·T Bonhoeffer
Jan 22, 1996·The Journal of Comparative Neurology·F HallböökN G Carri

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Citations

Jul 9, 1999·The Journal of Comparative Neurology·J Tenne-Brown, B Key
Jul 22, 1999·The Journal of Comparative Neurology·Q LiuJ A Marrs
Mar 31, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C D McCaigR Stewart
May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Vleminckx, R Kemler
Sep 28, 2010·Annals of Biomedical Engineering·A G VoyiadjisT Shinbrot
Mar 17, 2004·Current Opinion in Neurobiology·Kang Shen
Jan 7, 2004·Journal of Physiology, Paris·Christoph RediesJiankai Luo
Jun 20, 2001·Brain Research. Developmental Brain Research·S Heidmann, H Luksch
Nov 24, 2001·Brain Research. Developmental Brain Research·Q LiuP A Raymond
Jul 17, 1999·Brain Research. Developmental Brain Research·F Miskevich
May 5, 2004·Neurobiology of Aging·Wataru MatsunagaKenichi Isobe
Feb 11, 2003·Progress in Neurobiology·Nobuhiko YamamotoFujio Murakami
Apr 25, 2000·Progress in Neurobiology·C Redies
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B Ranscht
Oct 2, 2003·Current Opinion in Cell Biology·Masahito YamagataJoshua A Weiner
Oct 6, 1999·Current Opinion in Cell Biology·S Murase, E M Schuman
May 6, 1998·Current Opinion in Neurobiology·C E Holt, W A Harris
Mar 11, 1999·Current Opinion in Neurobiology·J R Sanes, M Yamagata
May 19, 2010·Molecular Psychiatry·T HattoriM Tohyama
Nov 30, 2006·Nature Reviews. Neuroscience·Masatoshi Takeichi
May 3, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y HonjoM Takeichi
Apr 13, 2000·The European Journal of Neuroscience·N E SavaskanR Nitsch
Nov 15, 2002·The European Journal of Neuroscience·Olivier RaineteauMartin E Schwab
Nov 28, 2002·The European Journal of Neuroscience·Lucia SchwyzerR Anne McKinney
Mar 20, 2010·Cold Spring Harbor Perspectives in Biology·Andrew D HubermanHerwig Baier
Apr 24, 2008·Development, Growth & Differentiation·Sachihiro C Suzuki, Masatoshi Takeichi
Oct 9, 2013·Annual Review of Cell and Developmental Biology·Herwig Baier
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Joshua R Sanes, Masahito Yamagata
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Jul 19, 2005·Annual Review of Neuroscience·Clarissa L WaitesCraig C Garner
Oct 1, 2009·Physiological Reviews·Sven Loebrich, Elly Nedivi

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