Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats

The European Journal of Neuroscience
Angela MüllnerM E Schwab

Abstract

Blocking the neurite growth inhibitor Nogo-A by neutralizing antibodies improves functional recovery after partial spinal cord injury. In parallel, regeneration and sprouting of cortico- and rubrospinal projections are increased and may partially explain the enhanced functional recovery. The serotonergic raphe-spinal tract, which plays a key regulatory role for spinal motor circuits, has not been analysed in detail with regard to its response to Nogo-A function blocking antibody treatment after spinal cord injury. We studied the effect of 2 weeks of intrathecal Nogo-A antibody application after partial thoracic spinal cord injury on the lamina-specific restitution of the serotonergic (5-HT) raphe-spinal projections to the mid-lumbar grey matter. Nine weeks after the lesion, the number of 5-HT fibres in Rexed's laminae 4 and 7 and the number of 5-HT-positive varicosities on motoneurons in lamina 9 returned to their lamina-specific preinjury levels in Nogo-A antibody-treated rats. By contrast, control antibody-treated animals showed only a moderate increase in 5-HT fibre density in the respective laminae, and the number of 5-HT-positive varicosities on motoneurons remained low. Our results suggest that the Nogo-A antibody-induced...Continue Reading

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Citations

Feb 22, 2012·Cell and Tissue Research·M A KoppJ M Schwab
Sep 15, 2014·Trends in Neurosciences·Meifan Chen, Binhai Zheng
Nov 10, 2009·Current Opinion in Neurobiology·Pascale Boulenguez, Laurent Vinay
Jul 22, 2009·Molecular and Cellular Neurosciences·Zixuan CaoFrank S Walsh
Jun 29, 2010·Annals of Neurology·Roman R GonzenbachMartin E Schwab
Jul 16, 2010·Annals of the New York Academy of Sciences·Björn Zörner, Martin E Schwab
Apr 18, 2015·Neural Regeneration Research·Jian-Wei WangYa-Feng Zhang
Mar 19, 2014·Current Opinion in Neurobiology·Martin E Schwab, Stephen M Strittmatter
May 21, 2011·Experimental Neurology·Jae K Lee, Binhai Zheng
May 3, 2011·Experimental Neurology·Michelle L Starkey, Martin E Schwab
Dec 3, 2014·Neuropharmacology·Aline Barroso Spejo, Alexandre L R Oliveira
May 13, 2014·Cell Transplantation·Wise Young
Oct 27, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Evan Deneris, Patricia Gaspar
Oct 2, 2013·Brain : a Journal of Neurology·Janine BeauparlantGrégoire Courtine
Jun 8, 2017·Frontiers in Cellular Neuroscience·Anne TeissierPatricia Gaspar
Jun 5, 2019·Nature Medicine·Grégoire Courtine, Michael V Sofroniew

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