PMID: 3766125Jan 1, 1986Paper

Laminar distribution of neocortical senile plaques in senile dementia of the Alzheimer type

Acta Neuropathologica
C DuyckaertsP Berthaux

Abstract

A prospective longitudinal study was undertaken in a geriatric hospital on women over 75 years of age, clinically diagnosed as either intellectually normal or having senile dementia of the Alzheimer type (SDAT) of varying degrees of severity. Mental impairment was assessed prospectively. Fifteen brains from this population were studied to evaluate quantitatively the distribution of senile plaques (SP) in relation to cortical lamination. SP density in four neocortical areas (first temporal gyrus; supramarginal gyrus calcarine area; precentral gyrus) was significantly correlated with the degree of mental impairment. SP distribution in the cortical layers was evaluated by an indirect method and appeared to be fairly constant from one case to another. Significantly higher SP densities were observed in layers II and III of the temporal and occipital samples, while minimal values were noted in layer I. Lower densities of SP were found in layers V and IV of the occipital and temporal lobes. These data suggest a selective vulnerability of some areas of cortical projections in SDAT.

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Citations

Jan 1, 1989·Acta Neuropathologica·T DuongA B Scheibel
Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
Aug 1, 1995·Journal of the Neurological Sciences·D L SparksJ C Hunsaker
Jan 1, 1994·Journal of Neuroscience Methods·C DuyckaertsJ J Hauw
Sep 1, 1991·Neurobiology of Aging·J W UngerR W Hamill
May 1, 1996·Neurobiology of Aging·H Adle-BiassetteJ J Hauw
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J J HauwP Henry
May 5, 2000·Neurobiology of Aging·Y M ArendsJ J Hauw
Jan 24, 2002·Neurobiology of Aging·Mark A LovellWilliam R Markesbery
Apr 26, 2003·Neurobiology of Aging·Wieneke P MetsaarsCharles Duyckaerts
Jul 1, 1997·Neurobiology of Aging·C Duyckaerts, J J Hauw
May 1, 1997·Neurobiology of Aging·C DuyckaertsJ J Hauw
Nov 27, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·R A. ArmstrongN J. Cairns

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