PMID: 6108982Jan 1, 1980

Laminar distribution of putative neurotransmitter amino acids and ligand binding sites in the dog olfactory bulb

Journal of Neurochemistry
N S NadiF L Margolis

Abstract

Coronal sections of frozen dog olfactory bulb have been dissected into four anatomically distinct layers. The laminar distribution of ten amino acids, the dipeptide carnosine, and nine [3H]ligand binding sites in these layers was determined. GABA and tyrosine levels were highest in the mitral cell-granule cell layer, and glutamate levels were slightly elevated in the glomerular layer. The distributions of all other amino acids did not show significant differences across the layers. Carnosine was predominantly localized in the fiber and glomerular layers. With the exception of quinuclidinyl benzilate, the [3H]ligand binding sites showed more discrete distributions. Muscimol, diazepam, kainic acid, and spiroperidol binding were predominantly localized in the mitral cell-granule cell layer, where clonidine binding was at a minimum. Dihydromorphine binding was high in both the fiber and the mitral cell-granule cell layers. Carnosine binding was maximal in the glomerular layer. The implications of these observations with regard to biochemical and neurophysiological data are discussed.

References

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Citations

May 7, 2002·Journal of Neuroscience Research·Rinat TabakmanRon Kohen
Apr 24, 1981·European Journal of Pharmacology·L R MeyersonA S Lippa
Nov 20, 1992·Brain Research. Developmental Brain Research·M S PognettoD Cantino
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd
Sep 29, 1999·Progress in Neurobiology·L BonfantiA Fasolo
Nov 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C C WooM Leon
Jan 28, 2014·PloS One·Hao JiaGopikrishna Deshpande
Nov 17, 2009·Neurological Research·Christof RennerFrank Gaunitz
Mar 24, 2016·Journal of Molecular Recognition : JMR·Muthuraman PanduranganDoo Hwan Kim
Feb 22, 2007·The Journal of Comparative Neurology·Angel PorterosJosé Ramón Alonso
Feb 24, 2007·Synapse·Nestor G DavilaPaul Q Trombley

Related Concepts

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Glutamic Acids
Cytochemistry
Ligands
Accessory Olfactory Bulb
Neurohormones

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