Laminar Inflammation Responses in the Oligofructose Overload Induced Model of Bovine Laminitis

Frontiers in Veterinary Science
Jiafeng DingHongbin Wang

Abstract

Bovine laminitis causes substantial economic losses and animal welfare problems in dairy farms worldwide. Previously published studies have reported that the inflammatory response plays a central role in the pathogenesis of the disease. To our knowledge, inflammation associated with bovine laminitis induced by high levels of exposure to oligofructose (OF) has not been reported and characterized. In fact, the disease manifestations in this model closely approximate those of clinical laminitis. The objective of this study was to characterize the inflammatory response in OF-induced bovine laminitis. A total of 12 Chinese Holstein dairy heifers were utilized in this study. The heifers were randomly divided into two groups, treatment (n = 6) and control (n = 6). The treatment group heifers were administered OF solutions via a stomach tube (dose: 17 g/kg of body weight). Upon development of a lameness score of 2 with consecutive positive reactions in the same claw, they would be humanely euthanized. Control heifers were administered deionized water (dose: 2 L/100 kg of body weight) and humanely euthanized at 72 h. Real-time quantitative PCR (qPCR) assays were performed to determine the messenger RNA (mRNA) concentrations of inflammat...Continue Reading

References

Jul 1, 1997·The British Journal of Surgery·M G Davies, P O Hagen
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kuniaki EjimaMark A Perrella
Jul 3, 2003·Journal of Dairy Science·J G C J SomersJ H M Metz
Sep 18, 2004·Journal of Dairy Science·M B ThoefnerP H Andersen
Dec 2, 2004·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·P BoonthamO Eremin
Jul 13, 2005·Thrombosis Research·Sacha ZeerlederWalter A Wuillemin
Jul 20, 2005·Journal of Dairy Science·M B ThoefnerS S Nielsen
Dec 1, 1992·New Zealand Veterinary Journal·J J Vermunt
Sep 20, 2005·Veterinary Immunology and Immunopathology·S J BlackJ Belknap
Dec 13, 2005·Critical Care Medicine·Philip O Scumpia, Lyle L Moldawer
Feb 24, 2006·Nature Reviews. Immunology·Martin F BachmannBenjamin J Marsland
Jul 11, 2006·Journal of Pharmacological Sciences·Naoyuki Matsuda, Yuichi Hattori
Oct 13, 2006·Journal of Leukocyte Biology·Marco E Bianchi
Jan 24, 2009·Journal of Dairy Science·A M DanscherM B Thoefner
Jan 6, 2010·Reproduction, Fertility, and Development·Pablo Bermejo-AlvarezDimitrios Rizos
Jan 12, 2010·Journal of Dairy Science·A M DanscherO Wattle
Jun 10, 2010·Journal of Innate Immunity·Hanna Katrien de JongWillem Joost Wiersinga
Dec 15, 2010·Equine Veterinary Journal·Britta S LeiseJ Belknap
Aug 9, 2012·The Veterinary Journal·J N Huxley
Jun 19, 2013·Virulence·Willem Joost WiersingaTom van der Poll
Jul 16, 2013·Journal of Dairy Science·D van der SpekH Bovenhuis
Jul 24, 2015·BMC Veterinary Research·Shu-Wei DongZhi-Qiang Yang
Dec 26, 2015·The Journal of Infection·Ilaria UmbroAnna Paola Mitterhofer
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto
Aug 9, 2016·Veterinary Immunology and Immunopathology·Jennifer D GodmanJ Belknap
Nov 12, 2016·International Journal of Molecular Sciences·Leonardo LorenteAlejandro Jiménez
Aug 6, 2017·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Feb 17, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yudai TakataniNaoyuki Matsuda
Mar 21, 2018·Animal : an International Journal of Animal Bioscience·K Dolecheck, J Bewley
Apr 21, 2018·BMC Veterinary Research·Chenxu ZhaoXinwei Li
May 15, 2018·Current Medicinal Chemistry·Miguel D FerrerAntoni Sureda
May 22, 2019·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Ramon Teixeira CostaReinaldo Salomão
Jul 5, 2019·BMC Veterinary Research·Alejandra I HidalgoRafael Agustín Burgos

Citations

Jan 5, 2021·Frontiers in Veterinary Science·Shuaichen LiNa Zhang
Nov 19, 2020·Animals : an Open Access Journal From MDPI·Carolina ManosalvaRafael Agustín Burgos

Related Concepts

Cattle Diseases
Claw
Inflammation
Interleukin-1 beta
Interleukin-6
Lameness, Animal
Macrophage
Plasminogen Activator Inhibitor 1
Peptides
Problem

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