Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex

ENeuro
Li-Wen HuangDesdemona Fricker

Abstract

The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projections to the lateral mammillary nucleus (LMN), involved in generating the head direction signal. The intrinsic properties of projecting neurons will influence the pathway-specific transmission of activity. Here, we used projection-specific labeling of presubicular neurons to identify MEC-, LMN-, and ATN-projecting neurons in mice. MEC-projecting neurons located in superficial layers II/III were mostly regular spiking pyramidal neurons, and we also identified a Martinotti-type GABAergic neuron. The cell bodies of LMN-projecting neurons were located in a well-delimited area in the middle portion of the PrS, which corresponds to layer IV. The physiology of LMN projecting, pyramidal neurons stood out with a tendency to fire in bursts of action potentials (APs) with rapid onset. These properties may be uniquely adapted to reliably transmit visual landmark information with short latency to upstream LMN. Neurons projecting to ATN were located...Continue Reading

Citations

Mar 15, 2018·Journal of Neurophysiology·Shahaf Weiss, Dori Derdikman
Feb 10, 2019·The Journal of Comparative Neurology·Luis PuellesMargaret Martínez-de-la-Torre
May 3, 2018·Journal of Neurophysiology·Stefano ColettaAndrea Burgalossi
Jul 25, 2019·Frontiers in Molecular Neuroscience·Brook A L Perry, Anna S Mitchell
Jul 30, 2019·Frontiers in Neural Circuits·Yoshiko Honda, Takahiro Furuta
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Rocío Valle-BautistaAnayansi Molina-Hernández
Jul 4, 2021·Neuroscience and Biobehavioral Reviews·Brook A L PerryAnna S Mitchell

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

Volocity
MATLAB
Neurolucida
pClamp
Axograph

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.