Abstract
Amyloid fibril formation is believed to be a nucleation-dependent polymerization process which may be influenced by various other factors with important consequences for the development, prevention or treatment of amyloidosis. We have previously shown that laminin inhibits A beta peptide fibril formation in vitro. Here we present a kinetic study that indicates laminin to be a potent anti-amyloidosis factor, as it not only inhibited A beta 1-40 fibril aggregation, but also inhibited the aggregation of the Dutch A beta 1-40 variant, a peptide with a higher capacity to aggregate than the wild-type A beta 1-40. The inhibitory effect of laminin on amyloid fibril formation was not overcome by the addition of pre-formed A beta fibrils, suggesting that laminin inhibits the fibril elongation process. At the present time, however, we cannot rule out the possibility that laminin also affects the initial nucleation process of A beta fibril formation. On other hand, laminin was not able to counteract the amyloid fibril formation promoted by acetylcholinesterase (AChE), another component of the amyloid deposits found in AD brains. The effect of laminin may be important as an inhibitor of A beta amyloidogenesis in vivo, specifically at the le...Continue Reading
References
Jun 1, 1992·Journal of Neuroscience Research·S MurtomäkiP Liesi
Nov 10, 1992·Biochemistry·J Engel
Dec 1, 1991·Journal of Neuroscience Research·L S PerlmutterH C Chui
Apr 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P D Yurchenco, J C Schittny
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S G van DuinenB Frangione
Nov 1, 1995·Experimental Neurology·T OdaT F Holzman
Nov 3, 1995·The Journal of Biological Chemistry·S JanciauskieneS Eriksson
Aug 4, 1995·Biochemical and Biophysical Research Communications·M ChenH L Fernandez
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·K C EvansP T Lansbury
Feb 17, 1995·The Journal of Biological Chemistry·C SotoN C Inestrosa
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M C KibbeyH K Kleinman
Mar 1, 1993·Protein Science : a Publication of the Protein Society·H LeVine
May 11, 1993·Biochemistry·J T JarrettP T Lansbury
Jun 18, 1993·Cell·J T Jarrett, P T Lansbury
Aug 1, 1995·Biophysical Journal·C L Shen, R M Murphy
Apr 1, 1996·Neuron·N C InestrosaJ Garrido
Apr 1, 1996·The Journal of Cell Biology·A De ArcangelisP Simon-Assmann
Apr 12, 1996·The Journal of Biological Chemistry·L O TjernbergC Nordstedt
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·B V ZlokovicJ Ghiso
Aug 2, 1996·The Journal of Biological Chemistry·D J Selkoe
Aug 1, 1996·Journal of Neurochemistry·J F Ghersi-EgeaJ D Fenstermacher
Jun 28, 1996·Neuroscience Letters·J WegielH Le Vine
Dec 1, 1995·Neuroscience Letters·A AlvarezN C Inestrosa
Sep 24, 1996·Biochemical and Biophysical Research Communications·C SotoB Frangione
Nov 8, 1996·Neuroscience Letters·F C BronfmanN C Inestrosa
May 9, 1997·The Journal of Biological Chemistry·L O TjernbergC Nordstedt
May 20, 1997·Biochemistry·H NaikiK Nakakuki
Jan 1, 1997·Annual Review of Biochemistry·J D Harper, P T Lansbury
Citations
Oct 31, 2000·Journal of Neuroscience Research·G M CastilloA D Snow
Jan 25, 2011·Acta Neuropathologica·Cheryl A HawkesRoxana O Carare
Aug 2, 2002·Life Sciences·Yoichi KiuchiMasaaki Kimura
Sep 1, 2000·Brain Research. Brain Research Reviews·G V De Ferrari, N C Inestrosa
Jul 20, 2002·Peptides·Carlos MorganNibaldo C Inestrosa
Jun 3, 1999·Neuroscience Letters·A MonjiN Tashiro
Aug 1, 2012·PloS One·Cheryl A HawkesRoxana O Carare
Apr 22, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·J B Ancsin, R Kisilevsky
Dec 22, 2012·Brain, Behavior, and Immunity·Veronica LifshitzDan Frenkel
Feb 19, 2013·Aging Cell·Cheryl A HawkesRoxana O Carare
Jun 20, 2014·Brain Pathology·Cheryl A HawkesRoxana O Carare
Jan 15, 2005·Progress in Neurobiology·Carlos MorganNibaldo C Inestrosa
May 27, 2004·The American Journal of Pathology·Ariel E ReyesNibaldo C Inestrosa
Feb 16, 2000·Molecular and Cellular Neurosciences·S L CotmanG J Cole
Jun 8, 1999·FEBS Letters·F J Muñoz, N C Inestrosa
Oct 7, 2014·Frontiers in Aging Neuroscience·Alan W J MorrisCheryl A Hawkes
Feb 26, 2016·Scientific Reports·Shereen NizariCheryl A Hawkes
Apr 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Morgan, N C Inestrosa
Aug 4, 2018·Biological Reviews of the Cambridge Philosophical Society·Abhijit Nirwane, Yao Yao
Nov 4, 2004·The Journal of Biological Chemistry·Linda SöderbergJan Näslund
Jul 31, 1999·Journal of Neurochemistry·B DrouetT Pillot
Feb 23, 2021·Reviews in the Neurosciences·Galina YankovaAndrey Tulupov