PMID: 9547001Apr 18, 1998Paper

Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
F C BronfmanN C Inestrosa

Abstract

Amyloid fibril formation is believed to be a nucleation-dependent polymerization process which may be influenced by various other factors with important consequences for the development, prevention or treatment of amyloidosis. We have previously shown that laminin inhibits A beta peptide fibril formation in vitro. Here we present a kinetic study that indicates laminin to be a potent anti-amyloidosis factor, as it not only inhibited A beta 1-40 fibril aggregation, but also inhibited the aggregation of the Dutch A beta 1-40 variant, a peptide with a higher capacity to aggregate than the wild-type A beta 1-40. The inhibitory effect of laminin on amyloid fibril formation was not overcome by the addition of pre-formed A beta fibrils, suggesting that laminin inhibits the fibril elongation process. At the present time, however, we cannot rule out the possibility that laminin also affects the initial nucleation process of A beta fibril formation. On other hand, laminin was not able to counteract the amyloid fibril formation promoted by acetylcholinesterase (AChE), another component of the amyloid deposits found in AD brains. The effect of laminin may be important as an inhibitor of A beta amyloidogenesis in vivo, specifically at the le...Continue Reading

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Citations

Aug 2, 2002·Life Sciences·Yoichi KiuchiMasaaki Kimura
Sep 1, 2000·Brain Research. Brain Research Reviews·G V De Ferrari, N C Inestrosa
Jul 20, 2002·Peptides·Carlos MorganNibaldo C Inestrosa
Apr 22, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·J B Ancsin, R Kisilevsky
Dec 22, 2012·Brain, Behavior, and Immunity·Veronica LifshitzDan Frenkel
Jun 20, 2014·Brain Pathology·Cheryl A HawkesRoxana O Carare
Jan 15, 2005·Progress in Neurobiology·Carlos MorganNibaldo C Inestrosa
Oct 7, 2014·Frontiers in Aging Neuroscience·Alan W J MorrisCheryl A Hawkes
Feb 26, 2016·Scientific Reports·Shereen NizariCheryl A Hawkes
Apr 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Morgan, N C Inestrosa
Aug 4, 2018·Biological Reviews of the Cambridge Philosophical Society·Abhijit Nirwane, Yao Yao
Feb 23, 2021·Reviews in the Neurosciences·Galina YankovaAndrey Tulupov

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