Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury.

Intensive Care Medicine
Masahiko KatayamaSatoru Hashimoto

Abstract

Laminin-5, a cell adhesive molecule expressed solely by epithelium, is known to enhance epithelial cell migration and repair of injured epithelium, after its essential component gamma2-chain is processed proteolytically. Our previous study revealed circulating levels of amino-terminal fragment of laminin gamma2-chain (G2F) reflect epithelial tumor invasiveness in carcinoma patients, but its physiological role in alveolar epithelial injury remains unknown. Sampling of epithelial lining fluids or pulmonary edema fluids from patients with acute lung injury (ALI) or related diseases was performed. Plasma samples were obtained from them at the time of disease onset or later. G2F concentrations were determined by immunoassay constructed by ourselves. We found a significantly higher amount of G2F in pulmonary edema and epithelial lining fluids of patients with ALI, as compared with those with the other respiratory diseases. Their plasma levels were also elevated significantly early at the onset of ALI (mean +/- SD; 147 +/- 82 ng/ml in non-surviving and 90 +/- 56 in surviving patients) as compared with those in the patients with cardiogenic pulmonary edema (59 +/- 36) or idiopathic pulmonary fibrosis (37 +/- 17), indicating alveolar ep...Continue Reading

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Citations

Dec 19, 2014·Journal of Intensive Care·Seitaro Fujishima
Oct 2, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Minnie MalikWilliam H Catherino
Mar 20, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Maneesh Bhargava, Chris H Wendt
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Jan 11, 2019·International Journal of Molecular Sciences·Hiroshi YasudaMotoharu Seiki
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Nov 30, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hongwei LiHuaiyong Chen

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