PMID: 8945763Nov 8, 1996Paper

Laminin inhibits amyloid-beta-peptide fibrillation

Neuroscience Letters
F BronfmanN C Inestrosa

Abstract

Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-beta-peptide (A beta) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/A beta protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit A beta fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.

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Citations

May 21, 1998·Brain Research·A MonjiN Tashiro
Aug 2, 2002·Life Sciences·Yoichi KiuchiMasaaki Kimura
Sep 1, 2000·Brain Research. Brain Research Reviews·G V De Ferrari, N C Inestrosa
Jul 20, 2002·Peptides·Carlos MorganNibaldo C Inestrosa
Mar 7, 2014·Journal of Molecular Neuroscience : MN·A G HenriquesO A B da Cruz e Silva
Dec 17, 2014·The Journal of Chemical Physics·Jiajia LiuRuhong Zhou
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Oct 7, 2014·Frontiers in Aging Neuroscience·Alan W J MorrisCheryl A Hawkes
Jan 1, 1999·Nutritional Neuroscience·M P CuajungcoA I Bush
Jan 1, 2009·Expert Opinion on Drug Discovery·Claudio Soto, Zane Martin
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Jul 12, 2002·Journal of Neuroscience Research·Edouard Palu, Päivi Liesi
Apr 23, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bruno PermanneClaudio Soto
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Jul 28, 2016·Chemistry & Biodiversity·Amira MiraKuniyoshi Shimizu

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