Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons.

Developmental Neurobiology
Elyanne M RatcliffeMichael D Gershon

Abstract

Vagal sensory axons navigate to specific sites in the bowel during fetal life. Netrin/deleted in colorectal cancer (DCC) were found to mediate the attraction of vagal sensory axons to the fetal mouse gut. We tested the hypothesis that laminin-111 can reverse the chemoattractive effects of netrin and act as a stop signal for vagal sensory axons. Laminin-111-expressing cells were located in the E12 and E16 mouse bowel by in situ hybridization. At E12, these cells extended centrifugally from the endoderm; by E16, laminin-111 expressing cells were found in the mucosa and outer gut mesenchyme. A similar pattern was seen in preparations of E13 and E15 mouse gut labeled with antibodies to laminin. Application of DiI to nodose ganglia identified vagal sensory axons growing into the fetal bowel. These terminals were found to avoid concentrations of laminin or to terminate at laminin-delimited boundaries. Soluble laminin inhibited the preferential growth of nodose neurites toward netrin-secreting cells (p < 0.01). This effect was mimicked by a peptide, YIGSR, a sequence within the beta1 chain of laminin-111 (p < 0.004) and antagonized by a peptide, IKVAV, a sequence within the alpha1 chain of laminin-111. Antibodies to beta1-integrins we...Continue Reading

References

Nov 4, 1992·Journal of the National Cancer Institute·M C KibbeyH K Kleinman
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T KanemotoH K Kleinman
Jul 31, 1989·Biochemical and Biophysical Research Communications·G C SephelH K Kleinman
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M SasakiY Yamada
Aug 1, 1994·Cell Adhesion and Communication·M A SteppR O Hynes
Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Bronner-Fraser
Oct 18, 1996·Cell·K Keino-MasuM Tessier-Lavigne
Mar 13, 1998·Gastroenterology·Q Aziz, D G Thompson
Apr 16, 1998·FEBS Letters·I Bushkin-Harav, U Z Littauer
Jul 22, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J R LukasR Mayr
Feb 3, 1999·Annals of the New York Academy of Sciences·P Simon-AssmannA De Arcangelis
May 26, 1999·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·T WedelH J Krammer
Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·M D Gershon
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H Colognato, P D Yurchenco
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Terry L Powley, Robert J Phillips
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H R BerthoudD Grundy
Sep 15, 2004·Current Opinion in Cell Biology·Peter D Yurchenco, William G Wadsworth
Feb 24, 2005·Cell Cycle·Sotiris N Nikolopoulos, Filippo G Giancotti
Jun 28, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Monique AumailleyPeter D Yurchenco
Aug 19, 2006·The Journal of Comparative Neurology·Elyanne M RatcliffeMichael D Gershon
Sep 8, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christophe FaureMichael D Gershon
Jun 26, 2007·The Journal of Biological Chemistry·Fiona I SchneidersManuel Koch

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Citations

Apr 20, 2012·Stem Cells and Development·Gerhard W HillRobert Keith Duncan
Nov 19, 2010·Regenerative Medicine·Swati Pradhan, Mary C Farach-Carson
Oct 27, 2011·Biomaterials·Shirley N MasandDavid I Shreiber
Dec 15, 2010·Autonomic Neuroscience : Basic & Clinical·Elyanne M Ratcliffe
Aug 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E M RatcliffeE A Fox
Nov 20, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David GoldbergElyanne M Ratcliffe
Jun 10, 2010·The Journal of Comparative Neurology·Michelle C Murphy, Edward A Fox
Jun 30, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kelly L HepworthElyanne M Ratcliffe
Sep 5, 2013·Brain Research·M L LemonsM L Condic
Apr 27, 2016·Developmental Biology·Toshihiro UesakaHideki Enomoto
Feb 20, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael B MontalbanoMichael J Pitman
May 4, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jonathan I Lake, Robert O Heuckeroth
Jul 27, 2018·Nature Reviews. Neuroscience·Meenakshi Rao, Michael D Gershon
Feb 9, 2018·Wellcome Open Research·Alexander M J Eve, James C Smith

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