Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

Cells
Julien GuindeElise Kaspi

Abstract

Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of new biomarkers is essential to improve the differential diagnosis between cancer subtypes, to select the most appropriate therapy, and to establish prognostic correlations. Nuclear abnormalities are hallmarks of carcinoma cells and are used as cytological diagnostic criteria of malignancy. Lamins (divided into A- and B-types) are localized in the nuclear matrix comprising nuclear lamina, where they act as scaffolding protein, involved in many nuclear functions, with regulatory effects on the cell cycle and differentiation, senescence and apoptosis. Previous studies have suggested that lamins are involved in tumor development and progression with opposite results concerning their prognostic role. This review provides an overview of lamins expression in lung cancer and the relevance of these findings for disease diagnosis and prognosis. Furthermore, we discuss the link between A-type lamins expression in lung carcinoma cells and nuclear deformability, epithelial to mesenchymal tr...Continue Reading

References

Aug 1, 1992·Seminars in Cell Biology·E A Nigg
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Jan 1, 1986·Experimental Cell Research·G Krohne, R Benavente
Jan 1, 1988·Annual Review of Cell Biology·L Gerace, B Burke
Apr 19, 1996·The Journal of Biological Chemistry·B M MachielsJ L Broers
Jun 1, 1997·Histochemistry and Cell Biology·J L BroersF C Ramaekers
Sep 2, 1998·Journal of Structural Biology·N StuurmanU Aebi
Mar 18, 2000·Biochemical and Biophysical Research Communications·F GuilakR Burgkart
Nov 2, 2002·The British Journal of Dermatology·M OguchiS Taniguchi
Apr 19, 2003·Science·Annachiara De Sandre-GiovannoliNicolas Lévy
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Sep 3, 2004·Nature Reviews. Cancer·Daniele ZinkJeffrey A Nickerson
Nov 2, 2004·Nature Cell Biology·Chris J Hutchison, Howard J Worman
Apr 5, 2005·Nature Genetics·Azra KrekNikolaus Rajewsky
Aug 16, 2005·Current Opinion in Cell Biology·Dirk JunghansRolf Kemler
Aug 19, 2005·Current Opinion in Cell Biology·Pamela CowinSarah J Hatsell
Sep 8, 2005·The Journal of Cell Biology·Jin-Wu TsaiRichard B Vallee
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Apr 29, 2006·Science·Paola Scaffidi, Tom Misteli
Jul 4, 2006·Physiological Reviews·J L V BroersC J Hutchison
Jul 11, 2006·The Journal of Biological Chemistry·Jan LammerdingRichard T Lee
Sep 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·J David PajerowskiDennis E Discher
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert F PlaceRajvir Dahiya
May 17, 2008·Cancer Research·Tamer T OnderRobert A Weinberg
Aug 21, 2008·PloS One·Naomi D WillisChristopher J Hutchison
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amaia LujambioManel Esteller
Jan 16, 2009·Journal of Experimental & Clinical Cancer Research : CR·Zhengrong WuFei Zhao
Feb 13, 2009·Journal of Cellular and Molecular Medicine·Miron ProkocimerYosef Gruenbaum
Aug 6, 2009·Biochemical and Biophysical Research Communications·Melissa CrawfordSerge P Nana-Sinkam
Feb 23, 2010·Nature Cell Biology·Li MaRobert A Weinberg
Jul 2, 2010·Cancer Biology & Therapy·Perry S Mongroo, Anil K Rustgi
May 31, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E J Th BeltG A Meijer
Jun 2, 2011·Chinese Journal of Cancer·Callinice D Capo-chichiXiang-Xi Xu
Jun 28, 2011·Cell Cycle·Abena B RedwoodSusana Gonzalo

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Citations

May 20, 2020·PLoS Computational Biology·Chao KongYing-Cheng Lai
Sep 30, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kanchan KumariSandip K Mishra

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Methods Mentioned

BETA
transfection
biopsies
biopsy

Clinical Trials Mentioned

NCT01829971

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