Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation

Annual Review of Biochemistry
Yosef Gruenbaum, Roland Foisner

Abstract

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.

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Methods Mentioned

BETA
electron microscopy
transmission electron microscopy
electron tomography
nuclear translocation
DamID
immunoprecipitation
Hi-C
transgenic

Software Mentioned

Hi

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