Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma

Leukemia & Lymphoma
K MatsuoM Harada

Abstract

We report a chronic hepatitis B virus (HBV) carrier with non-Hodgkin lymphoma (NHL) who developed HBV hepatitis following conventional dose chemotherapy and was successfully treated with lamivudine and glycyrrhizin. A 55 year-old male patient with primary testicular NHL (diffuse large B-cell type) relapsed. During the salvage chemotherapy, the patient showed elevated serum levels of transaminase and HBV-DNA due to HBV reactivation. Treatment with lamivudine, an antiviral nucleoside analog, was started at a dose of 100mg/day. Shortly after the treatment the HBV-DNA level was suppressed, and sustained elevation of transaminase levels were normalized after additional treatment with glycyrrhizin. This experience suggests that lamivudine combined with glycyrrhizin may be effective for controlling HBV replication and treating chemotherapy-induced HBV hepatitis in chronic HBV carriers with NHL.

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Citations

Aug 30, 2011·Cell Biochemistry and Biophysics·Wen HuangPeng Xie
Jun 1, 2008·Hepatology International·George K K Lau
Jan 28, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·James R JacobYoung-Ho Kim
Mar 16, 2005·The Lancet Infectious Diseases·David A GronebergPeter Zabel
May 8, 2016·Journal of Medical Virology·Jieying PuXi Huang
Oct 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manal M HassanJames L Abbruzzese

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