PMID: 8951213Nov 1, 1996Paper

Lamotrigine--an update

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
M J Brodie

Abstract

Lamotrigine (LTG) inhibits repetitive high frequency firing in depolarised neurones by selectively prolonging slow inactivation of the sodium channel, thereby suppressing the release of excitatory amino acids. It has been shown to be effective in 11 pivotal double-blind add-on trials in patients with refractory partial seizures with or without secondary generalisation. Subsequent anecdotal data support its efficacy for typical and atypical absences, myoclonic jerks, tonic or clonic seizures, Lennox-Gastaut syndrome and infantile spasms. Most recently LTG has been compared with carbamazepine and phenytoin in double-blind trials in patients with newly diagnosed partial and primary and secondary generalised tonic-clonic seizures. At the doses used, its efficacy was similar to the older agents for all seizure types, but LTG was better tolerated than both of the older agents. The commonest side-effects with LTG include headache, nausea, diplopia, dizziness, ataxia and tremor. Rash occurs in fewer than 5% patients. Its incidence can be reduced by starting treatment with a low dose, particularly in patients receiving concomitant sodium valproate which inhibits LTG metabolism. Enzyme inducers, such as carbamazepine, phenytoin and pheno...Continue Reading

Citations

Feb 25, 2003·International Clinical Psychopharmacology·Fabio Lopes Rocha, Claudia Hara
Oct 3, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Patrick SantensPaul Boon
Jun 7, 2013·The Cochrane Database of Systematic Reviews·Eleanor C HancockStuart W Edwards
Nov 14, 2014·CNS Drugs·J van GaalenB P C van de Warrenburg
Sep 15, 2006·Seminars in Dialysis·Rubeen K IsraniJeffrey S Berns

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Related Papers

Epilepsia
J A Messenheimer
Seizure : the Journal of the British Epilepsy Association
S J Wallace
© 2021 Meta ULC. All rights reserved