Lamotrigine and catamenial epilepsy

Seizure : the Journal of the British Epilepsy Association
Ronit GiladYair Lampl

Abstract

Catamenial epilepsy (CE) is characterized by epileptic seizures in the female occurring rhythmatically with the menstrual cycle. Hormonal mechanisms have been proposed as a cause of this epileptic form. Few reports about the efficacy of anti-epileptic drugs (AEDs) have been published. We studied prospectively women with CE who were treated with lamotrigine (LTG) for a period of 3 months in order to evaluate its efficacy, measuring the progesterone levels before and after LTG at the same time. LTG seemed to be efficacious in 66% of women, meaning the disappearance of seizures or reduction of 50% or more of the number of seizures. The reported side effects were few and mild, and the drug was well tolerated. Serum progesterone levels were found to rise during LTG treatment.

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Citations

Jun 25, 2014·Neurobiology of Disease·Doodipala Samba Reddy
May 15, 2012·Hormones and Behavior·Doodipala Samba Reddy
Dec 17, 2011·European Journal of Pharmacology·Hyo-Seok NaChong-Soo Kim
Jun 10, 2009·Experimental Neurology·Annelyn Torres-ReveronTeresa A Milner
Oct 5, 2010·British Journal of Pharmacology·Sahruh TurkmenInga-Maj Johansson
Jan 28, 2015·Epilepsy & Behavior : E&B·Maurine M CobabeNancy Foldvary-Schaefer
Apr 14, 2015·Experimental Neurology·James D'AmourHelen E Scharfman
Oct 27, 2009·Seizure : the Journal of the British Epilepsy Association·Mahmoud HosseiniAli Gorji
May 27, 2011·Seizure : the Journal of the British Epilepsy Association·Burcu ÖztürkÇiğdem Özkara
Jul 18, 2016·Pharmacology, Biochemistry, and Behavior·Doodipala Samba Reddy
Oct 1, 2016·The Journal of Emergency Medicine·Basem F Khishfe
Jun 13, 2014·Brain : a Journal of Neurology·Viktor K JirsaChristophe Bernard

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