Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study

Journal of Affective Disorders
E Sherwood BrownA John Rush

Abstract

Bipolar disorder (BPD) is associated with high rates of substance abuse. We previously reported favorable results with lamotrigine in 30 patients with BPD and cocaine dependence. This report examines lamotrigine therapy in an additional 32 cocaine dependent patients. Data on these 32 participants are presented as a replication study. In addition, we extend the previous findings by combining data from both groups, and by exploring predictors of response. Participants received a baseline evaluation and assessment for up to 36weeks with the 17-item Hamilton Rating Scale for Depression (HRSD(17)), Young Mania Rating Scale (YMRS), Brief Psychiatric Rating Scale (BPRS(18)), and Cocaine Craving Questionnaire (CCQ). Urine samples were obtained, and participants reported drug use during the previous week. In the replication sample (n=32), significant improvements were observed in HRSD(17), YMRS, BPRS(18), and CCQ (baseline to exit), as well as on dollars/week spent on cocaine. In the extension study, the original sample (n=30) and the replication sample (n=32) were combined for a total of 62 participants in the intent-to-treat sample. HRSD(17), YMRS, BPRS(18), and CCQ scores, as well as dollars spent on cocaine, decreased significantly....Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Nov 21, 1990·JAMA : the Journal of the American Medical Association·D A RegierF K Goodwin
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Dec 1, 1993·Drug and Alcohol Dependence·S T TiffanyJ E Henningfield
Mar 26, 1998·The American Journal of Drug and Alcohol Abuse·A MargolinT R Kosten
Jan 10, 2003·Bipolar Disorders·E Sherwood BrownLeonardo Bobadilla
Mar 14, 2003·The Journal of Clinical Psychiatry·E Sherwood BrownLeonardo Bobadilla
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 25, 2003·The Journal of Clinical Psychiatry·Joseph R CalabreseUNKNOWN Lamictal 605 Study Group

❮ Previous
Next ❯

Citations

Oct 5, 2007·Current Psychiatry Reports·Kathleen T BradyBryan K Tolliver
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni AddoloratoAntonello Bonci
May 19, 2007·Addiction Biology·Antonio Preti
Dec 3, 2014·Physiology & Behavior·Jadwiga Zalewska-KaszubskaPrzemysław Bieńkowski
Dec 4, 2015·Medical Hypotheses·Ming-Chyi HuangShih-Ku Lin
Apr 19, 2011·Epilepsy & Behavior : E&B·Kenneth R Kaufman
May 4, 2011·Pharmacology, Biochemistry, and Behavior·M Foster OliveRobert J Malcolm
Mar 6, 2010·Annals of the New York Academy of Sciences·Alan C Swann
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Jan 19, 2016·Revista de psiquiatrí́a y salud mental·Adrián Secades-Álvarez, Concepción Fernández-Rodríguez
Mar 17, 2017·The American Journal of Drug and Alcohol Abuse·Ihsan M Salloum, Edson Sherwood Brown
May 26, 2012·Journal of Psychopharmacology·A R Lingford-HughesUNKNOWN British Association for Psychopharmacology, Expert Reviewers Group
Jun 1, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stacy M Ku, Ming-Hu Han
May 12, 2019·Bipolar Disorders·Alexandria S ColesTony P George

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here