Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials.

The British Journal of Psychiatry : the Journal of Mental Science
John R GeddesGuy M Goodwin

Abstract

There is uncertainty about the efficacy of lamotrigine in bipolar depressive episodes. To synthesise the evidence for the efficacy of lamotrigine in bipolar depressive episodes. Systematic review and meta-analysis of individual patient data from randomised controlled trials comparing lamotrigine with placebo. Individual data from 1072 participants from five randomised controlled trials were obtained. More individuals treated with lamotrigine than placebo responded to treatment on both the Hamilton Rating Scale for Depression (HRSD) (relative risk (RR)=1.27, 95% CI 1.09-1.47, P=0.002) and Montgomery-Asberg Depression Rating Scale (MADRS) (RR=1.22, 95% CI 1.06-1.41, P=0.005). There was an interaction (P=0.04) by baseline severity of depression: lamotrigine was superior to placebo in people with HRSD score >24 (RR=1.47, 95% CI 1.16-1.87, P=0.001) but not in people with HRSD score < or =24 (RR=1.07, 95% CI 0.90-1.27, P=0.445). There is consistent evidence that lamotrigine has a beneficial effect on depressive symptoms in the depressed phase of bipolar disorder. The overall pool effect was modest, although the advantage over placebo was larger in more severely depressed participants.

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Apr 13, 1991·Lancet·P J EasterbrookD R Matthews
Jan 1, 1993·Statistical Methods in Medical Research·T C Chalmers, J Lau
Dec 6, 2000·Journal of Clinical Psychopharmacology·M A FryeR M Post
Jan 5, 2002·The American Journal of Psychiatry·John M Kane
Mar 7, 2002·Archives of General Psychiatry·Dennis S CharneyUNKNOWN Consensus Development Panel
Jun 5, 2002·Archives of General Psychiatry·Lewis L JuddMartin B Keller
Jul 12, 2002·Statistics in Medicine·Simon G Thompson, Julian P T Higgins
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Mar 10, 2004·Bipolar Disorders·Lauren B MarangellUNKNOWN STEP-BD Investigators
Sep 1, 2004·The American Journal of Psychiatry·Harm J GijsmanGuy M Goodwin
Oct 9, 2004·BMJ : British Medical Journal·John R Geddes, Andrea Cipriani
Jul 5, 2005·The American Journal of Psychiatry·Joseph R CalabreseJamie Mullen
Nov 18, 2006·Journal of Clinical Psychopharmacology·Michael E ThaseUNKNOWN BOLDER II Study Group
Mar 30, 2007·The New England Journal of Medicine·Gary S SachsMichael E Thase
Sep 1, 2000·Acta Neuropsychiatrica·D J KupferA G Mailinger

❮ Previous
Next ❯

Citations

Jul 31, 2012·Journal of Affective Disorders·I GrandeUNKNOWN SIN-DEPRES Group
May 15, 2013·Lancet·John R Geddes, David J Miklowitz
Feb 9, 2013·CNS Spectrums·Laura MusettiLiliana Dell'Osso
May 25, 2013·CNS Spectrums·Philip B MitchellCharles L Bowden
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua LiRichard C Shelton
Jun 7, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Sherwood BrownThomas J Carmody
Jan 7, 2011·The New England Journal of Medicine·Mark A Frye
Aug 18, 2012·Journal of Child and Adolescent Psychopharmacology·Ameena IsaBarbara J Coffey
Oct 7, 2011·The Primary Care Companion to CNS Disorders·Roger Sparhawk, S Nassir Ghaemi
May 13, 2014·Journal of Child and Adolescent Psychopharmacology·Seung-Hyun ShonHyo-Won Kim
Jul 6, 2014·European Journal of Pharmacology·Ramadhan OruchAnders Lund
Aug 20, 2014·The Medical Clinics of North America·Carolyn J Brenner, Stanley I Shyn
Jul 10, 2013·Journal of General Internal Medicine·Joseph M CerimeleJürgen Unützer
Nov 5, 2011·Current Psychiatry Reports·Claudia F BaldassanoJordan Coello
Oct 16, 2012·Current Psychiatry Reports·Michelle M Sidor, Glenda M MacQueen
Apr 14, 2010·Der Nervenarzt·H Grunze, S Dargel
Mar 27, 2013·Paediatric Drugs·Victoria E CosgroveKiki D Chang
May 6, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Steven M Baskin, Todd A Smitherman
Feb 10, 2016·Journal of Affective Disorders·Alina KarantiMikael Landén
May 4, 2010·Journal of Mental Health·Shibu P ThomasAnand Jayaraman
Nov 13, 2012·Expert Opinion on Pharmacotherapy·Charles L Bowden, Vivek Singh
Nov 1, 2011·Expert Opinion on Pharmacotherapy·Leslie Citrome
May 2, 2014·Expert Review of Neurotherapeutics·Cecilio AlamoPilar García-García
Oct 20, 2015·Expert Opinion on Pharmacotherapy·Charles L Bowden, Vivek Singh
Jul 1, 2009·Expert Review of Clinical Pharmacology·Vivek Datta, Anthony J Cleare
May 1, 2010·Expert Review of Clinical Pharmacology·Lindsey I SinclairAndrea L Malizia
Jul 19, 2012·Expert Opinion on Drug Metabolism & Toxicology·Peter NiemegeersBernard Gc Sabbe
Jun 29, 2014·Expert Opinion on Drug Safety·Mario A Cristancho, Michael E Thase
Jan 9, 2014·Expert Opinion on Emerging Drugs·Paul A Keedwell, Allan H Young
Feb 13, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Heinz GrunzeUNKNOWN WFSBP Task Force On Treatment Guidelines For Bipolar Disorders
Mar 8, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Wolfgang HufSiegfried Kasper
Jan 7, 2016·Journal of Psychiatric Research·Nadia IovienoGeorge I Papakostas
Aug 13, 2013·Journal of the Chinese Medical Association : JCMA·Ya-Mei BaiTung-Ping Su
Dec 20, 2011·Clinical Therapeutics·Shefali Srivastava, Terence A Ketter
Jan 4, 2012·L'Encéphale·L SamalinP-M Llorca
Oct 19, 2011·Pharmacology & Therapeutics·James Offord
Oct 12, 2012·Asian Journal of Psychiatry·Praveen Francis Abraham
Apr 19, 2011·Epilepsy & Behavior : E&B·Kenneth R Kaufman
Feb 5, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Arash Mowla, Ehsan Kardeh
Nov 3, 2010·Journal of Affective Disorders·Konstantinos N FountoulakisFrank Schmidt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.