PMID: 9429128Jan 16, 1998Paper

Lamotrigine in absence and primary generalized epilepsies

Journal of Child Neurology
M A Mikati, G L Holmes

Abstract

Although lamotrigine has been approved in the United States as adjunctive therapy for partial seizures in patients older than 12 years, there is increasing evidence that it is just as effective, if not more effective, in the treatment of generalized seizures. A large number of open-label studies and some single-blind data, all using lamotrigine as add-on therapy in patients with previously refractory generalized seizures, are available. Controlled studies, some on newly diagnosed, previously untreated patients with generalized seizures are ongoing. Investigations have demonstrated that patients with the following generalized seizure types improve with lamotrigine add-on therapy: Typical and atypical absence, atonic, generalized tonic-clonic, myoclonic, and clonic seizures. Response rates, defined as the percentage of patients with better than 50% reduction in seizure frequency, have been, depending on seizure type, in the range of 30% to 56%, with 0 to 33% of the patients becoming seizure free. The best responses have been noted in typical and atypical absences, and atonic seizures. Children and adults appear to have comparable responses. In addition, add-on studies in patients with specific, previously refractory, epilepsy syn...Continue Reading

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Citations

Feb 11, 2000·Pediatric Neurology·M FayadM Mikati
Jan 6, 1999·Seminars in Pediatric Neurology·D N Franz
Aug 25, 2001·Epilepsia·E Perucca
Aug 20, 2011·Epilepsy Currents·Jeffrey Buchhalter
Jan 20, 2004·Brain & Development·Giangennaro CoppolaAntonio Pascotto
Dec 6, 2006·Expert Review of Neurotherapeutics·Sheetal MalikLawrence J Hirsch
Oct 6, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Frank J E VajdaDavid Horgan
Jul 1, 2008·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ignacio ValenciaAgustín Legido
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Nov 9, 2016·Expert Review of Clinical Pharmacology·Venkata Ramesh YasamM J Nanjan
Sep 24, 2015·Pharmacological Reports : PR·Nuno Marques PiresPatrício Soares-da-Silva

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