PMID: 9416765Jan 1, 1997Paper

Lamotrigine inhibits the in situ activity of tyrosine hydroxylase in striatum of audiogenic seizure-prone and audiogenic seizure-resistant Balb/c mice

Life Sciences
J Vriend, N A Alexiuk

Abstract

Lamotrigine (LTG), an anticonvulsive drug, was tested for its effects on striatal content of DA and its metabolites, DOPAC and HVA, in audiogenic seizure-resistant (ER) and audiogenic seizure-prone (EP) lines of Balb/c mice. A single dose of LTG (20 mg/kg) prevented audiogenic seizures in seizure-prone mice, while reducing substantially the striatal content of the DA metabolite, DOPAC (to less than 50% of saline-injected controls) in both seizure-resistant and seizure-prone mice. LTG administration also resulted in significant reduction of striatal content of HVA. The in situ activity of tyrosine hydroxylase (TH) in extracts of striatum was significantly reduced by LTG administration in both ER and EP mice. These data show that DA synthesis in the striatum of mice is substantially reduced by LTG administration.

References

May 4, 1990·Neuroscience Letters·E G McGeer, S G Zhu
Jan 1, 1995·Annual Review of Physiology·A P Braun, H Schulman

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Citations

Jun 5, 2003·Physiology & Behavior·Leida M Botion, Maria Carolina Doretto
Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
Jul 23, 1999·Pharmacotherapy·A VermaR A Radtke
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I KidaK L Behar
Aug 12, 2006·Journal of Child Neurology
Oct 3, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Patrick SantensPaul Boon
Aug 27, 2019·The Tohoku Journal of Experimental Medicine·Andrea KovácsAnita Kamondi

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