Lamotrigine pharmacokinetics in patients receiving felbamate

Epilepsy Research
B E GidalG L Lensmeyer

Abstract

Drug interactions can significantly complicate the management of patients receiving multiple medications. It is essential therefore that potential pharmcokinetic interactions be evaluated as new antiepileptic medications are introduced. Lamotrigine (LTG) is a recently marketed medication whose pharmacokinetics are significantly influenced by concomitant drugs. Felbamate (FBM), another relatively new antiepileptic agent has been associated with multiple interactions including both enzyme induction and inhibition. The purpose of the present pilot study was to evaluate potential differences in lamotrigine kinetics in six patients concomitantly receiving FBM compared to five patients receiving lamotrigine as monotherapy. There was no statistically significant differences in either apparent LTG oral clearance (0.026 +/- 0.005 vs. 0.024 +/- 0.01 l/kg per h, respectively), or in mean elimination half-life (33.7 +/- 7.5 vs. 40.2 +/- 15.05 h, respectively). Oral clearance values in our patients are also consistent with data reported previously in the literature. Data from this pilot study suggest that a marked effect of FBM upon lamotrigine pharmacokinetics is unlikely.

Citations

Jul 19, 2008·Lancet Neurology·Lorraine V KaliaMichael W Salter
Oct 13, 2000·Fundamental & Clinical Pharmacology·M S Benedetti
Jan 24, 2002·Therapeutic Drug Monitoring·Houda HachadRene H Levy
Nov 1, 2002·Expert Review of Neurotherapeutics·Barry E GidalJacqueline A French
Mar 9, 2010·Thérapie·Danièle Bentué-FerrerUNKNOWN le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique

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