PMID: 9421101Jan 8, 1998Paper

Lamotrigine plasma concentrations in children and adults: influence of age and associated therapy

Therapeutic Drug Monitoring
D BattinoG Avanzini

Abstract

The effects of age and concomitant treatment on plasma lamotrigine (LTG) concentration/dose (C/D) ratios were retrospectively evaluated on 482 consecutive routine LTG determinations from 106 chronically-treated patients with epilepsy (40 children and adolescents aged younger than 16 years, and 66 adults aged 17 to 62 years). A linear dose/level relationship was observed in individual patients but not in the cumulative analysis, which failed to show any correlation between the administered LTG dose and plasma concentrations. In the adult group, there were no correlations between the administered LTG dose and plasma concentrations. Associated antiepileptic therapy affected the LTG concentration/dose ratio, which was significantly higher in the patients receiving valproic acid (3.4 +/- 2.0, n = 23) and significantly lower in those treated with enzyme-inducing antiepileptic drugs (0.6 +/- 0.5, n = 57) than in the patients receiving valproic acid in combination with enzyme-inducing antiepileptic drugs, ethosuximide, vigabatrin, or clobazam (1.9 +/- 1.6, n = 26). The LTG C/D ratios significantly increased with increasing plasma valproic acid concentrations, and significantly decreased with increasing phenytoin concentrations. The eff...Continue Reading

References

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Mar 1, 1994·Epilepsia·E SchlumbergerO Dulac
Dec 1, 1995·The Journal of Pediatrics·F M BesagG Hosking

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Citations

Aug 4, 2009·European Journal of Drug Metabolism and Pharmacokinetics·Mladena LalicMomir Mikov
Jul 28, 2006·European Journal of Clinical Pharmacology·A M AlmeidaM M Caramona
Jul 14, 2005·Journal of Clinical Psychopharmacology·Arne ReimersOlav Spigset
Aug 28, 2010·Journal of Biomedicine & Biotechnology·Sébastien ChateauvieuxMarc Diederich
Apr 3, 2012·Biological & Pharmaceutical Bulletin·Yoshiaki YamamotoYoshiyuki Kagawa
Jun 6, 2007·Drugs·Elon EisenbergNorberto Krivoy
Aug 17, 2010·Epilepsy & Behavior : E&B·Torbjörn TomsonInger Ohman
Feb 28, 2007·International Journal of Geriatric Psychiatry·Martha SajatovicThomas Thompson
Apr 1, 2016·Acta Neurologica Scandinavica·P RameyB Abou-Khalil
Apr 30, 2002·The Annals of Pharmacotherapy·Elaine Chong, L Lee Dupuis
Jan 22, 2002·Therapeutic Drug Monitoring·V ChanS E Tett
Sep 2, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Bader AlyahyaMartin Laliberté
Dec 23, 1998·British Journal of Clinical Pharmacology·R G MorrisB C Sallustio

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