LAMP1 expression is associated with poor prognosis in breast cancer

Oncology Letters
Qingqing WangQichao Ni

Abstract

Lysosome associated membrane protein-1 (LAMP1) is a heavily glycosylated lysosomal membrane protein, which is able to protect the lysosomal membrane from intracellular proteolysis. LAMP1 has been implicated in cancer development and progression. However, LAMP1 expression in breast cancer (BC) and its relationship with the clinical parameters of BC has not yet been fully investigated. In the present study, LAMP1 expression in BC was characterized by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) on 20 pairs of fresh-frozen BC and corresponding non-cancerous tissues. In addition, tissue microarray immunohistochemistry (TMA-IHC) was conducted on 143 BC and matched non-cancerous tissue samples. The results of RT-qPCR and TMA-IHC demonstrated that LAMP1 expression in BC tissues was significantly higher than in corresponding non-cancerous tissues. Furthermore, LAMP1 protein expression levels were significantly associated with histological grade (P=0.047), estrogen receptor expression (P=0.003), progesterone receptor expression (P=0.002), molecular classification (P=0.022), lymph node metastasis (P=0.033) and tumor-node-metastasis (TNM) stage (P=0.012). Multivariate analysis using Cox regression models and Kapl...Continue Reading

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Citations

Oct 1, 2020·International Journal of Molecular Sciences·Justyna GilMaria M Sąsiadek
Oct 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoying HeJunying Miao
Dec 11, 2020·Cancers·Xingjian Zhai, Yassine El Hiani
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Eda R MachadoAlessandra d'Azzo
May 16, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Jing Peng, Danhua Zhang

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Methods Mentioned

BETA
dissection
PCR
biopsies

Software Mentioned

STATA
tile
Primer Express

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