PMID: 9430313Jan 16, 1998Paper

Landau-Kleffner syndrome: metabolic abnormalities in temporal lobe are a common feature

Journal of Child Neurology
E A da SilvaH T Chugani

Abstract

Landau-Kleffner syndrome (acquired epileptic aphasia) is characterized by language regression following normal acquisition of language skills, accompanied by epileptiform abnormalities on the electroencephalogram (EEG) with or without clinical seizures. Continuous spikes and waves during slow wave sleep may be seen on the EEG, but are not required to make the diagnosis. Structural neuroimaging with computed tomography (CT) and magnetic resonance imaging (MRI) is typically normal. We have evaluated 17 children (aged 2.4 to 10.6 yr) with Landau-Kleffner syndrome using positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in order to determine whether there are metabolic abnormalities common to this syndrome. Patients were awake for the uptake period of FDG, and the EEG was monitored. On a visual analysis of the PET images, patients showed metabolic abnormalities in the temporal lobes. Two children had focal hypermetabolism in the left temporal cortex, one of whom also showed right temporal cortex hypometabolism. The remaining patients (n = 15) showed bilateral temporal hypometabolism, and comparison of these patients with a neurologically normal age-matched control group (n = 8) demonstrated significantly ...Continue Reading

References

Jul 3, 1978·European Journal of Pediatrics·K Kellermann
Jan 1, 1975·Journal of the American Academy of Child Psychiatry·I L HumphreyE R Bumpass
Mar 1, 1990·Developmental Medicine and Child Neurology·N Gordon
Nov 1, 1990·Epilepsia·C MarescauxG Franck
Oct 1, 1990·Journal of Child Neurology·R Nass, D Petrucha
Mar 1, 1991·Developmental Medicine and Child Neurology·P LermanS Kivity
Jul 1, 1991·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T W Deonna
Jul 1, 1991·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·P B Jayakar, S S Seshia
Dec 1, 1985·Developmental Medicine and Child Neurology·D V Bishop
Aug 1, 1989·Neuropediatrics·B J AnsinkH R van Dongen
May 1, 1980·Neurology·J F Mantovani, W M Landau
Dec 1, 1981·Epilepsia·G L HolmesZ Saunders
Jan 1, 1982·Clinical EEG (electroencephalography)·I Rodriguez, E Niedermeyer
May 1, 1995·Archives of Disease in Childhood·R E Appleton
Jul 1, 1993·Journal of Child Psychology and Psychiatry, and Allied Disciplines·T Deonna
Mar 1, 1995·Journal of Child Neurology·P J RintahakaR Sankar
Dec 1, 1996·Revista de neurologia·J J OrtegaA L Serrano
Aug 1, 1957·Neurology·W M LANDAU, F R KLEFFNER

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Citations

Aug 7, 2010·Brain : a Journal of Neurology·Michael SiniatchkinUlrich Stephani
May 22, 2002·Revista de neurologia·M J PabloA Sáenz de Cabezón
Aug 18, 2009·Epilepsia·Laura MascettiPierre Maquet
May 24, 2012·Neuroscience and Biobehavioral Reviews·Radwa A B BadawyAnthony S Harvey
Jun 18, 2003·Human Brain Mapping·Steve MajerusMarie-Noëlle Metz-Lutz
Apr 25, 2006·Brain & Development·Aimee F LuatRobert Rothermel

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