PMID: 10391611Jul 3, 1999

Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Shinji TakahashiHidenori Toyooka

Abstract

To examine the effect of landiolol (ONO-1101), a new ultra-short acting and highly selective beta blocker, on epinephrine-induced ventricular arrhythmias in halothane-anesthetized dogs. We administered five different doses (0, 0.1, 0.5, 1.0, 10 microg x kg(-1) x min(-1)) landiolol and determined the dysrhythmogenic dose of epinephrine (DDE), defined as the smallest dose producing four or more PVCs within 15 sec, at each dose of landiolol and after cessation of infusion. The control value of DDE during 1.3 MAC halothane anesthesia was 1.26 +/- 0.44 (mean +/- SD) microg x kg(-1) x min(-1) and the corresponding plasma concentration of epinephrine (PCE) was 12.2 +/- 8.3 ng x ml(-1). Concomitant administration of 10 microg x kg(-1) x min(-1) landiolol increased DDE and corresponding PCE (P < 0.05). At 30 min after cessation of landiolol infusion, DDE and corresponding PCE returned to the control values. Landiolol, at a dose of 10 microg x kg(-1) x min(-1), has an antiarrhythmic effect on epinephrine-induced ventricular arrhythmias in dogs during anesthesia with halothane.

References

Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y HayashiI Yoshiya
Jan 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I DimichH Shiang
Jun 1, 1992·Chemical & Pharmaceutical Bulletin·S IguchiM Kawamura
Dec 1, 1990·Anesthesia and Analgesia·A DysonJ M Lipton
Feb 1, 1989·Anesthesia and Analgesia·M I GoldC A Skillman

Citations

Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shinji TakahashiHidenori Toyooka
Oct 4, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shinji TakahashiHidenori Toyooka
Oct 12, 2012·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Donald R Miller

Related Concepts

Landiolol
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Cardiac Depressants
Canis familiaris
Drug Interactions
Medihaler-Epi
Narcotan
Morpholines
Carmol

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