Landmark-based evaluation of a deformable motion correction for DCE-MRI of the liver

International Journal of Computer Assisted Radiology and Surgery
Jan StrehlowAndrea Schenk

Abstract

Annotation of meaningful landmark ground truth on DCE-MRI is difficult and laborious. Motion correction methods applied to DCE-MRI of the liver are thus mostly evaluated using qualitative or indirect measures. We propose a novel landmark annotation scheme that facilitates the generation of landmark ground truth on larger clinical datasets. In our annotation scheme, landmarks are equally distributed over all time points of all available dataset cases and annotated by multiple observers on a per-pair basis. The scheme is used to annotate 26 DCE-MRI of the liver. A subset of the ground truth is used to optimize parameters of a deformable motion correction. Several variants of the motion correction are evaluated on the remaining cases with respect to distances of corresponding landmarks after registration, deformation field properties, and qualitative measures. A landmark ground truth on 26 cases could be generated in under 12 h per observer with a mean inter-observer distance below the mean voxel diagonal. Furthermore, the landmarks are spatially well distributed within the liver. Parameter optimization significantly improves the performance of the motion correction, and landmark distance after registration is 2 mm. Qualitative ev...Continue Reading

References

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Jun 14, 2015·European Radiology·Elmar M MerkleMengsu Zeng

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Citations

Oct 24, 2018·International Journal of Computer Assisted Radiology and Surgery·Nadine SpahrAndrea Schenk

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