Landscapes and archipelagos: spatial organization of gene regulation in vertebrates

Trends in Cell Biology
Thomas Montavon, Denis Duboule

Abstract

Vertebrate genes controlling critical developmental processes are often regulated by complex sets of global enhancer sequences, located at a distance, within neighboring gene deserts. Recent technological advances have made it possible to investigate the spatial organization of these 'regulatory landscapes'. The integration of such datasets with information on chromatin status, transcriptional activity and nuclear localization of these loci, as well as the effects of genetic modifications thereof, may bring a more comprehensive understanding of tissue- and/or stage-specific gene regulation in both normal and pathological contexts. Here, we review the impact of recent technological advances on our understanding of large-scale gene regulation in vertebrates, by focusing on paradigmatic gene loci.

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Citations

Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nicolas LonfatDenis Duboule
Nov 13, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ignacio MaesoJosé Luis Gómez-Skarmeta
Jun 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Carlos Gómez-MarínJosé Luis Gómez-Skarmeta
Apr 30, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Malte Spielmann, Stefan Mundlos
Feb 19, 2013·Current Opinion in Genetics & Development·Peter H L Krijger, Wouter de Laat
Aug 10, 2013·Blood·Dominic van Essen
Nov 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Thomas MontavonDenis Duboule
Mar 10, 2018·Nature Communications·Christoph LippsTobias May
Apr 12, 2018·Cell Reports·Jurian SchuijersRichard Allen Young

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