PMID: 8986144Feb 1, 1997Paper

Langerhans cell histiocytosis: an exploratory epidemiologic study of 177 cases

Medical and Pediatric Oncology
M HamreL L Robison

Abstract

There is little information available regarding epidemiologic risk factors for Langerhans cell histiocytosis (LCH). An exploratory investigation was conducted using information obtained from parents of 177 cases of LCH diagnosed before 21 years of age (median 2 years). Utilizing data available from the Children's Cancer Group, LCH cases were compared to two matched control groups including 614 patients diagnosed with a variety of childhood cancers and 318 community controls. Questionnaire data included information on demographics, prenatal and perinatal factors, complications in the neonatal period, environmental exposures, family medical history, and childhood exposures. Factors found to be statistically significantly associated with an increased risk of LCH included: maternal urinary tract infection during the index pregnancy, feeding problems during infancy, and blood transfusions during infancy. Use of supplemental vitamins was associated with a significantly decreased risk of LCH. Results from this exploratory study provide a basis for speculation on potential etiologic risk factors for LCH. Future epidemiologic investigations of LCH need to consider the presenting disease characteristics in assessing possible etiologic fa...Continue Reading

References

Aug 1, 1975·The Journal of Pediatrics·E Lahey
Nov 1, 1986·Journal of Clinical Immunology·B T Shannon, W A Newton
Oct 1, 1985·The Journal of Pediatrics·M E LaheyD Hammond
Sep 1, 1985·Journal of the American Academy of Dermatology·N B EsterlyF Gonzalez-Crussi
Jan 1, 1985·Lung·T W Marcy, H Y Reynolds
Jan 1, 1983·Medical and Pediatric Oncology·M Matus-RidleyA T Meadows
Sep 1, 1981·Medicine·J S GreenbergerJ R Cassady
Jan 1, 1980·Medical and Pediatric Oncology·J M Slater, O J Swarm
Jul 21, 1994·The New England Journal of Medicine·C L WillmanD G Gilliland

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Citations

Oct 16, 2015·Hematology/oncology Clinics of North America·Chalinee Monsereenusorn, Carlos Rodriguez-Galindo
Dec 19, 2012·Survey of Ophthalmology·Martina C HerwigHans E Grossniklaus
Jun 24, 2008·Survey of Ophthalmology·Curtis E Margo, Darin R Goldman
Jul 28, 2012·Acta Paediatrica·Selma O AkefeldtJan-Inge Henter
Mar 22, 2012·Pediatric Blood & Cancer·Rajkumar VenkatramaniRima Jubran
Apr 30, 1998·Hematology/oncology Clinics of North America·H S NicholsonM E Nesbit
Jan 15, 2015·Pediatric Blood & Cancer·Karina Braga RibeiroCarlos Rodriguez-Galindo
Jul 6, 2014·Scottish Medical Journal·Allison MartinRobert Carachi
Feb 13, 2008·Pediatric Blood & Cancer·Helen StålemarkJan-Inge Henter
Feb 9, 2008·Pediatric Blood & Cancer·Aurélie Guyot-GoubinJacqueline Clavel
Mar 14, 2008·Pediatric Blood & Cancer·Jane Salotti
Jan 1, 2009·Fetal and Pediatric Pathology·Max TrotzNeil J Sebire
Oct 12, 2011·Anais Brasileiros De Dermatologia·Joana OrlePatrícia Makino Rezende
Jan 2, 2020·Surgical Neurology International·Kacper Kostyra, Bogusław Kostkiewicz
Aug 24, 2018·Cell Communication and Signaling : CCS·Ichiro MurakamiFrancis Jaubert
Apr 19, 2015·Cell Communication and Signaling : CCS·Ichiro MurakamiTadashi Yoshino
Dec 22, 1999·British Journal of Haematology·M AricòC Danesino
Nov 26, 2002·Hematology·Robert J ArceciPeter D Emanuel
Aug 6, 2021·Laryngo- rhino- otologie·Fabian Sommer
Feb 16, 2006·Actas dermo-sifiliográficas·Marta Valdivielso, Celso Bueno
Jul 21, 2010·Pediatrics·Bengt KällénPetra Otterblad Olausson

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